| Adrenal responses to stress. | |
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MedLine Citation:
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PMID: 21061156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Based on concepts proposed by Langley, Cannon, and Selye, adrenal responses to stress occur in a syndrome that reflects activation of the sympathoadrenal system and hypothalamic–pituitary–adrenocortical (HPA) axis; and a "stress syndrome" maintains homeostasis in emergencies such as "fight or flight" situations, but if the stress response is excessive or prolonged then any of a variety of clinical disorders can arise. The idea of a unitary sympathoadrenal system does not account for evidence that different stressors elicit different patterns of autonomic responses, with exposure to some stressors differentially affecting sympathetic noradrenergic and adrenomedullary hormonal activities. Instead, adrenomedullary responses to stressors are more closely tied to adrenocortical than to sympathetic noradrenergic responses. Distress involves concurrent activation of the HPA and adrenomedullary neuroendocrine systems. |
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Authors:
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David S Goldstein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cellular and molecular neurobiology Volume: 30 ISSN: 1573-6830 ISO Abbreviation: Cell. Mol. Neurobiol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2011-01-10 Completed Date: 2011-04-14 Revised Date: 2011-07-26 |
Medline Journal Info:
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Nlm Unique ID: 8200709 Medline TA: Cell Mol Neurobiol Country: United States |
Other Details:
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Languages: eng Pagination: 1433-40 Citation Subset: IM |
Affiliation:
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Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5N220, 9000 Rockville Pike, 10 Center Drive, MSC-1620, Bethesda, MD 20892-1620, USA. goldsteind@ninds.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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physiology* Allostasis Animals Feedback, Physiological Homeostasis Humans Stress, Physiological* |
| Grant Support | |
ID/Acronym/Agency:
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Z01 NS003033-01/NS/NINDS NIH HHS; Z01 NS003033-02/NS/NINDS NIH HHS; ZIA NS003033-03/NS/NINDS NIH HHS; ZIA NS003033-04/NS/NINDS NIH HHS |
| Comments/Corrections | |
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