Document Detail


Adrafinil-induced orofacial dyskinesia.
MedLine Citation:
PMID:  15300665     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We describe the first case of orofacial abnormal movements induced by adrafinil, a vigilance promoting agent of the same pharmacological class as modafinil. The dyskinesias did not spontaneously recover despite adrafinil withdrawal for a 4-month period. They were secondly dramatically improved by tetrabenazine, a presynaptic dopaminergic depleting drug which was introduced after the 4-month adrafinil-free period.
Authors:
Stéphane Thobois; Jing Xie; Helena Mollion; Isabelle Benatru; Emmanuel Broussolle
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  19     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-09     Completed Date:  2004-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  965-6     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Movement Disorder Society
Affiliation:
Department of Neurology, The Pierre Wertheimer Neurological Hospital, Lyon, France. stephane.thobois@chu-lyon.fr
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MeSH Terms
Descriptor/Qualifier:
Aged
Anti-Dyskinesia Agents / therapeutic use
Antihypertensive Agents / adverse effects*
Dyskinesia, Drug-Induced / drug therapy,  etiology*
Humans
Hydroxamic Acids / adverse effects*
Hypertension / drug therapy
Male
Tetrabenazine / therapeutic use
Chemical
Reg. No./Substance:
0/Anti-Dyskinesia Agents; 0/Antihypertensive Agents; 0/Hydroxamic Acids; 58-46-8/Tetrabenazine; 63547-13-7/adrafinil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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