Document Detail

Adoptive transfer of antigen-specific CD4+ T cells in the treatment of metastatic melanoma.
MedLine Citation:
PMID:  18852719     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Clinical investigations of adoptive therapy in solid tumors have primarily focused on CD8(+) cells. A study by Hunder et al. is the first to demonstrate the significance of antigen-specific CD4(+) T cells. An in vitro method was used to treat a patient with metastatic melanoma using autologous CD4(+) cells against NY-ESO-1 (cancer and/or testis antigen 1). The successful adoptive transfer of antigen-specific CD4(+) cells to a patient with metastatic melanoma is not only an important technical accomplishment but also provides increased understanding of tumor immunity. This report demonstrates an impressive persistence of adoptively transferred cells together with durability of clinical response. CD4(+) T cells that target a particular antigen can augment T-cell responses to other tumor-associated targets. These observations underline the importance of ongoing research for effective, non-toxic immune therapies for cancer.
F Stephen Hodi; David E Fisher
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Publication Detail:
Type:  Comment; Journal Article     Date:  2008-10-14
Journal Detail:
Title:  Nature clinical practice. Oncology     Volume:  5     ISSN:  1743-4262     ISO Abbreviation:  -     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-26     Completed Date:  2009-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101226509     Medline TA:  Nat Clin Pract Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  696-7     Citation Subset:  -    
Melanoma Program, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
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MeSH Terms
Comment On:
N Engl J Med. 2008 Jun 19;358(25):2698-703   [PMID:  18565862 ]

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