Document Detail

Adoptive transfer of antigen-specific CD4+ T cells in the treatment of metastatic melanoma.
MedLine Citation:
PMID:  18852719     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Clinical investigations of adoptive therapy in solid tumors have primarily focused on CD8(+) cells. A study by Hunder et al. is the first to demonstrate the significance of antigen-specific CD4(+) T cells. An in vitro method was used to treat a patient with metastatic melanoma using autologous CD4(+) cells against NY-ESO-1 (cancer and/or testis antigen 1). The successful adoptive transfer of antigen-specific CD4(+) cells to a patient with metastatic melanoma is not only an important technical accomplishment but also provides increased understanding of tumor immunity. This report demonstrates an impressive persistence of adoptively transferred cells together with durability of clinical response. CD4(+) T cells that target a particular antigen can augment T-cell responses to other tumor-associated targets. These observations underline the importance of ongoing research for effective, non-toxic immune therapies for cancer.
F Stephen Hodi; David E Fisher
Related Documents :
7720089 - Polymorphonuclear neutrophils enhance suppressive activities of anti-cd3-induced cd4+ s...
1827429 - Cytokine production by t helper cell subpopulations during prolonged in vitro stimulation.
19770269 - Tslp and il-7 use two different mechanisms to regulate human cd4+ t cell homeostasis.
10229269 - Functional characteristics of human peripheral blood alpha/betatcr+, cd4- and cd8- doub...
8301219 - Involvement of cd4 in interleukin-6 secretion by u937 monocytic cells stimulated with t...
2766889 - Resolving leukocytes using axial light loss.
11844219 - The mast cell in wound healing.
9368639 - Quantitative assessment of myelin basic protein-reactive t cell entry to the central ne...
24662049 - Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters.
Publication Detail:
Type:  Comment; Journal Article     Date:  2008-10-14
Journal Detail:
Title:  Nature clinical practice. Oncology     Volume:  5     ISSN:  1743-4262     ISO Abbreviation:  -     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-26     Completed Date:  2009-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101226509     Medline TA:  Nat Clin Pract Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  696-7     Citation Subset:  -    
Melanoma Program, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Comment On:
N Engl J Med. 2008 Jun 19;358(25):2698-703   [PMID:  18565862 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Vitamin D and musculoskeletal health.
Next Document:  Anal cancer: is neoadjuvant cisplatin chemotherapy or chemoradiotherapy friend or foe?