| Adoptive immunotherapy for cancer: harnessing the T cell response. | |
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MedLine Citation:
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PMID: 22437939 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Immunotherapy based on the adoptive transfer of naturally occurring or gene-engineered T cells can mediate tumour regression in patients with metastatic cancer. Here, we discuss progress in the use of adoptively transferred T cells, focusing on how they can mediate tumour cell eradication. Recent advances include more accurate targeting of antigens expressed by tumours and the associated vasculature, and the successful use of gene engineering to re-target T cells before their transfer into the patient. We also describe how new research has helped to identify the particular T cell subsets that can most effectively promote tumour eradication. |
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Authors:
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Nicholas P Restifo; Mark E Dudley; Steven A Rosenberg |
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Publication Detail:
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Type: Journal Article Date: 2012-03-22 |
Journal Detail:
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Title: Nature reviews. Immunology Volume: 12 ISSN: 1474-1741 ISO Abbreviation: Nat. Rev. Immunol. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: England |
Other Details:
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Languages: eng Pagination: 269-81 Citation Subset: IM |
Affiliation:
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Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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