Document Detail

Adoptive immunotherapy of cancer: accomplishments and prospects.
MedLine Citation:
PMID:  6362866     Owner:  NLM     Status:  MEDLINE    
Adoptive immunotherapy is an approach to cancer treatment that has not received significant evaluation in cancer patients. Recent developments in modern cellular immunology have expanded the opportunities for utilizing adoptive immunotherapy in humans. A variety of animal models have been developed utilizing the adoptive transfer of immune cells that can mediate the regression of established murine tumors. Analyses of these models are defining the important criteria necessary for the application of this approach to humans. Studies of the immune response of human cells to autologous tumors are identifying cells with antitumor reactivity that may be of value in the treatment of human malignancy. Preliminary clinical studies have been performed demonstrating the feasibility of infusing large numbers of activated lymphoid cells into humans. Adoptive immunotherapy is an approach to the treatment of cancer that deserves further study.
S A Rosenberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer treatment reports     Volume:  68     ISSN:  0361-5960     ISO Abbreviation:  Cancer Treat Rep     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-02-29     Completed Date:  1984-02-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607107     Medline TA:  Cancer Treat Rep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  233-55     Citation Subset:  IM    
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MeSH Terms
Cell Line
Immunization, Passive*
Lymphocytes / immunology
Lymphoma / immunology,  therapy
Neoplasms / immunology,  therapy*
Neoplasms, Experimental / immunology,  therapy*
Sarcoma, Experimental / radiotherapy
Skin Transplantation

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