Document Detail

Adoption of celecoxib and rofecoxib: a nationwide database study.
MedLine Citation:
PMID:  15811167     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Cyclooxygenase 2-selective non-steroidal anti-inflammatory drugs (NSAIDs, coxibs) are recommended primarily for patients at high risk of gastrointestinal bleeding, most of them being elderly. Our objective was to describe and analyse patient- and physician-related factors affecting the adoption of celecoxib and rofecoxib 2 years after their launch in Finland. METHODS: Retrospective analysis of the nationwide Prescription Register. Physicians who had issued at least 200 reimbursed prescriptions in 2002 (n = 12 033, 80% of working-age Finnish physicians) were involved in the analysis. RESULTS AND DISCUSSION: Excluding patients with rheumatoid arthritis (RA), almost one-fifth (18%) of NSAIDs prescriptions were for coxibs. In patients with RA the share was 25%. The share of coxib prescriptions of all NSAIDs increased with age of the patient. Over one half (58%) of coxib prescriptions were issued for patients under 65 years of age. Specialists in physical and rehabilitation medicine were the fastest adopters of coxibs: one-third of their NSAID prescriptions in 2002 were for coxibs. Primary care physicians were the most conservative both in adopting and favouring coxibs. CONCLUSIONS: Coxibs have gained the status of standard prescription NSAIDs within a few years. Their use should be restricted to patients who could benefit most from the use. Routine prescribing of expensive new drugs increases the drug bill without additional health gain.
A Helin-Salmivaara; R Huupponen; A Virtanen; T Klaukka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pharmacy and therapeutics     Volume:  30     ISSN:  0269-4727     ISO Abbreviation:  J Clin Pharm Ther     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-06     Completed Date:  2005-11-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8704308     Medline TA:  J Clin Pharm Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  145-52     Citation Subset:  IM    
Centre for Pharmacotherapy Development, Helsinki, Finland.
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MeSH Terms
Age Factors
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Databases, Factual / statistics & numerical data,  trends*
Drug Utilization Review / methods
Finland / epidemiology
Insurance, Pharmaceutical Services / trends,  utilization
Lactones / therapeutic use*
Medicine / statistics & numerical data
Physician's Practice Patterns / statistics & numerical data,  trends
Product Surveillance, Postmarketing / economics,  methods
Pyrazoles / therapeutic use*
Retrospective Studies
Sex Factors
Sulfonamides / therapeutic use*
Sulfones / therapeutic use*
Time Factors
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Lactones; 0/Pyrazoles; 0/Sulfonamides; 0/Sulfones; 0/rofecoxib; 169590-42-5/celecoxib

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