| Adoption of celecoxib and rofecoxib: a nationwide database study. | |
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MedLine Citation:
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PMID: 15811167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: Cyclooxygenase 2-selective non-steroidal anti-inflammatory drugs (NSAIDs, coxibs) are recommended primarily for patients at high risk of gastrointestinal bleeding, most of them being elderly. Our objective was to describe and analyse patient- and physician-related factors affecting the adoption of celecoxib and rofecoxib 2 years after their launch in Finland. METHODS: Retrospective analysis of the nationwide Prescription Register. Physicians who had issued at least 200 reimbursed prescriptions in 2002 (n = 12 033, 80% of working-age Finnish physicians) were involved in the analysis. RESULTS AND DISCUSSION: Excluding patients with rheumatoid arthritis (RA), almost one-fifth (18%) of NSAIDs prescriptions were for coxibs. In patients with RA the share was 25%. The share of coxib prescriptions of all NSAIDs increased with age of the patient. Over one half (58%) of coxib prescriptions were issued for patients under 65 years of age. Specialists in physical and rehabilitation medicine were the fastest adopters of coxibs: one-third of their NSAID prescriptions in 2002 were for coxibs. Primary care physicians were the most conservative both in adopting and favouring coxibs. CONCLUSIONS: Coxibs have gained the status of standard prescription NSAIDs within a few years. Their use should be restricted to patients who could benefit most from the use. Routine prescribing of expensive new drugs increases the drug bill without additional health gain. |
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Authors:
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A Helin-Salmivaara; R Huupponen; A Virtanen; T Klaukka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical pharmacy and therapeutics Volume: 30 ISSN: 0269-4727 ISO Abbreviation: J Clin Pharm Ther Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-06 Completed Date: 2005-11-03 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8704308 Medline TA: J Clin Pharm Ther Country: England |
Other Details:
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Languages: eng Pagination: 145-52 Citation Subset: IM |
Affiliation:
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Centre for Pharmacotherapy Development, Helsinki, Finland. arja.helin-salmivaara@rohto.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Anti-Inflammatory Agents, Non-Steroidal / therapeutic use Child Databases, Factual / statistics & numerical data, trends* Drug Utilization Review / methods Finland / epidemiology Humans Insurance, Pharmaceutical Services / trends, utilization Lactones / therapeutic use* Medicine / statistics & numerical data Physician's Practice Patterns / statistics & numerical data, trends Product Surveillance, Postmarketing / economics, methods Pyrazoles / therapeutic use* Retrospective Studies Sex Factors Specialization Sulfonamides / therapeutic use* Sulfones / therapeutic use* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Lactones; 0/Pyrazoles; 0/Sulfonamides; 0/Sulfones; 0/rofecoxib; 169590-42-5/celecoxib |
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