Document Detail


Adolescent rickets in Saudi Arabia: a rich and sunny country.
MedLine Citation:
PMID:  12199329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this retrospective study from Saudi Arabia, which is a rich and sunny country, we report our experience with 34 adolescents (20 females, 10 males) with rickets. The commonest cause was vitamin D deficiency (58.8%) followed by rickets due to low calcium intake (11.8%) and genetic causes, including possible 25-hydroxylase deficiency (8.8%). The etiology of nutritional rickets is multifactorial, including lack of sun exposure and inadequate calcium intake. The clinical symptoms were nonspecific and therefore cases in this country are either underdiagnosed or missed. Vitamin D deficient patients needed an average of 19 months of treatment before recovery. High dose vitamin D plus calcium supplementation are recommended for treatment. Measures to prevent rickets in all age groups including adolescents are suggested. Further studies on nutritional and genetic forms of rickets are recommended.
Authors:
Mohamed A Abdullah; Hamad S Salhi; Lina A Bakry; Emi Okamoto; Abdullah M Abomelha; Brian Stevens; Fawzi M Mousa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  15     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:    2002 Jul-Aug
Date Detail:
Created Date:  2002-08-29     Completed Date:  2003-03-18     Revised Date:  2012-01-30    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  1017-25     Citation Subset:  IM    
Affiliation:
Division of Pediatric Endocrinology, Security Forces Hospital, Riyadh, Saudi Arabia. mabdullah@sfh.med.sa
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Calcium, Dietary / administration & dosage
Clothing / adverse effects
Cytochrome P-450 CYP27A1
Environmental Exposure
Female
Humans
Hyperparathyroidism / complications
Hypophosphatemia / complications
Male
Retrospective Studies
Rickets / etiology*,  genetics
Saudi Arabia
Steroid Hydroxylases / deficiency
Sunlight
Vitamin D Deficiency / complications
Chemical
Reg. No./Substance:
0/Calcium, Dietary; EC 1.14.-/Cytochrome P-450 CYP27A1; EC 1.14.-/Steroid Hydroxylases; EC 1.14.13.15/CYP27A1 protein, human

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