Document Detail

Adolescent case of Alexander disease: MR imaging and MR spectroscopy.
MedLine Citation:
PMID:  9492095     Owner:  NLM     Status:  MEDLINE    
A 17-year-old male was diagnosed as having Alexander disease from the clinical manifestations (psychomotor deterioration and megalencephaly), neuroradiologic findings (frontal dominant leukodystrophy), and elevation of alpha B-crystallin and heat shock protein 27 in the cerebrospinal fluid. He exhibited increased attenuation on computed tomography and T1 and T2 shortening on magnetic resonance imaging in the bilateral basal ganglia and thalamus. Some paramagnetic substances might be deposited in the basal ganglia and thalamus in the late stage of Alexander disease, at least 8 years after onset.
J Takanashi; K Sugita; Y Tanabe; H Niimi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  18     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-04-15     Completed Date:  1998-04-15     Revised Date:  2006-05-23    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  67-70     Citation Subset:  IM    
Department of Pediatrics, Faculty of Medicine, University of Chiba, Japan.
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MeSH Terms
Astrocytes / pathology*
Brain Diseases / enzymology,  pathology*
Crystallins / metabolism
Heat-Shock Proteins / metabolism
Inclusion Bodies / pathology*
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Nerve Tissue Proteins / metabolism
Psychomotor Performance*
Reg. No./Substance:
0/Crystallins; 0/Heat-Shock Proteins; 0/Nerve Tissue Proteins

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