Document Detail


Adolescent and young adult exposure to physical activity and breast density.
MedLine Citation:
PMID:  23377838     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The objective of this study is to examine the role of early lifetime exposure to physical activity on magnetic resonance imaging-determined breast density measures.
METHODS: Associations of adolescent (high school (ages 14-17 yr) and early adulthood, post-high school (ages 18-21 yr) and past year) leisure-time physical activity, as well as a principal component score including all three estimates, were examined with percent dense breast volume (%DBV) and absolute dense breast volume (ADBV) in a cross-sectional analysis of 182 healthy women, ages 25-29 yr, enrolled in the Dietary Intervention Study in Children Follow-up Study (DISC06). Generalized linear mixed models were used to examine associations after adjustment for relevant covariates for the entire analytic sample. Analyses were repeated in nulliparous women and hormonal contraceptive nonusers.
RESULTS: Physical activity during high school and post-high school were not statistically significantly related to %DBV or ADBV in multivariable models. Past year physical activity was positively related to %DBV in the unadjusted and partially adjusted models (P < 0.001 and P = 0.01, respectively), which did not adjust for body mass index (BMI). After additional adjustment for childhood and early adulthood BMI, this association became nonstatistically significant. The relation between past year physical activity and ADBV was not statistically significant. These findings were similar in nonusers of hormonal contraceptives. No statistically significant relations were found in nulliparous women or between the principal component score and %DBV or ADBV.
CONCLUSION: Results from this study are consistent with previous research suggesting that physical activity during adolescence and early adulthood is unrelated to breast density.
Authors:
Kelley Pettee Gabriel; Catherine Klifa; Adriana Pérez; Andrea M Kriska; Robin R High; Linda Snetselaar; Joanne F Dorgan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  45     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-17     Completed Date:  2014-03-20     Revised Date:  2014-08-04    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1515-23     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anthropometry
Body Mass Index
Breast / anatomy & histology*
Cross-Sectional Studies
Exercise / physiology*
Female
Humans
Magnetic Resonance Imaging
Texas
Young Adult
Grant Support
ID/Acronym/Agency:
R01CA104670/CA/NCI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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