| Adolescent offspring of mothers with chronic fatigue syndrome. | |
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MedLine Citation:
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PMID: 20159507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The goal of this study was to determine whether adolescent offspring of mothers with chronic fatigue syndrome (CFS) have higher prevalence of CFS and report more fatigue, greater pain sensitivity, more sleep problems, and poorer cardiopulmonary fitness in comparison with offspring with no exposure to maternal CFS. METHODS: A total of 26 adolescent offspring of 20 mothers diagnosed with CFS were compared with 45 adolescent offspring of 30 age-matched healthy control mothers. Study measures included structured interviews and medical and laboratory examinations for CFS; tender point examination; maximum oxygen uptake and perceived exertion; dolorimetry pain ratings; and questionnaires on fatigue severity and sleepiness. RESULTS: In comparison with offspring of healthy mothers, those exposed to mothers with CFS reported higher prevalence of fatigue of at least 1-month duration (23% vs. 4%), fatigue of 6 months or longer (15% vs. 2%), and met criteria for CFS (12% vs. 2%), although these differences only approached statistical significance. CFS and healthy mothers differed on almost all study outcomes, but offspring groups did not differ on measures of current fatigue severity, pain sensitivity, sleep, mean number of tender points, and cardiopulmonary fitness. CONCLUSIONS: The higher prevalence of fatiguing states in offspring of CFS mothers, despite the lack of statistical significance, suggests that familial factors may potentially play a role in developing chronically fatiguing states. Alternately, perturbations in pain sensitivity and cardiopulmonary fitness may be consequences of CFS. Future studies should focus on examining the impact of maternal CFS and associated disability on psychosocial functioning of offspring. |
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Authors:
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Mark S Smith; Dedra S Buchwald; Andy Bogart; Jack Goldberg; Wayne R Smith; Niloofar Afari |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-10-13 |
Journal Detail:
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Title: The Journal of adolescent health : official publication of the Society for Adolescent Medicine Volume: 46 ISSN: 1879-1972 ISO Abbreviation: J Adolesc Health Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-05-10 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 9102136 Medline TA: J Adolesc Health Country: United States |
Other Details:
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Languages: eng Pagination: 284-91 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Washington, Seattle, Washington, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child of Impaired Parents* Fatigue Syndrome, Chronic / epidemiology*, genetics*, physiopathology Female Humans Interviews as Topic Male Middle Aged Physical Fitness / physiology Questionnaires Washington / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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AI-038429/AI/NIAID NIH HHS; M01 RR000037-39/RR/NCRR NIH HHS; M01RR-00037/RR/NCRR NIH HHS; R01 AR051524-04/AR/NIAMS NIH HHS; R01AR051524/AR/NIAMS NIH HHS; U19 AI038429-07/AI/NIAID NIH HHS |
| Comments/Corrections | |
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