| Adolescent diet and subsequent serum hormones, breast density, and bone mineral density in young women: results of the Dietary Intervention Study in Children follow-up study. | |
| | |
MedLine Citation:
|
PMID: 20501774 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Adolescent diet is hypothesized to influence breast cancer risk. We evaluated the long-term effects of an intervention to lower fat intake among adolescent girls on biomarkers that are related to breast cancer risk in adults. METHODS: A follow-up study was conducted on 230 girls who participated in the Dietary Intervention Study in Children (DISC), in which healthy, prepubertal, 8 to 10 year olds were randomly assigned to usual care or to a behavioral intervention that promoted a reduced fat diet. Participants were 25 to 29 years old at follow-up visits. All tests of statistical significance are two-sided. RESULTS: In analyses that did not take account of diet at the time of the follow-up visit, the only statistically significant treatment group difference was higher bone mineral content in intervention group participants compared with usual care group participants; their mean bone mineral contents were 2,444 and 2,377 g, respectively. After adjustment for current diet, the intervention group also had statistically significantly higher bone mineral density and luteal phase serum estradiol concentrations. Serum progesterone concentrations and breast density did not differ by treatment group in unadjusted or adjusted analyses. CONCLUSIONS: Results do not support the hypothesis that consumption of a lower fat diet during adolescence reduces breast cancer risk via effects on subsequent serum estradiol and progesterone levels, breast density, or bone mineral density. It remains unclear, however, if the results are specific to the DISC intervention or are more broadly applicable. IMPACT: Modest reductions in fat intake during adolescence are unlikely to lower later breast cancer risk via long-term effects on the biomarkers measured. |
| | |
Authors:
|
Joanne F Dorgan; Lea Liu; Catherine Klifa; Nola Hylton; John A Shepherd; Frank Z Stanczyk; Linda G Snetselaar; Linda Van Horn; Victor J Stevens; Alan Robson; Peter O Kwiterovich; Norman L Lasser; John H Himes; Kelley Pettee Gabriel; Andrea Kriska; Elizabeth H Ruder; Carolyn Y Fang; Bruce A Barton |
Related Documents
:
|
8283194 - The risk of multiple sclerosis in the u.s.a. in relation to sociogeographic features: a... 19656644 - The role of mediterranean type of diet on the development of cancer and cardiovascular ... 11562264 - Polyphenolic compounds: interactions with the gut and implications for human health. 3756804 - Diet and breast cancer in causation and therapy. 15590644 - Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoe-defici... 11680094 - Effect of azadirachta indica extract on plasma lipid levels in human malaria. |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2010-05-25 |
Journal Detail:
|
Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Volume: 19 ISSN: 1538-7755 ISO Abbreviation: Cancer Epidemiol. Biomarkers Prev. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-09 Completed Date: 2010-10-15 Revised Date: 2011-03-03 |
Medline Journal Info:
|
Nlm Unique ID: 9200608 Medline TA: Cancer Epidemiol Biomarkers Prev Country: United States |
Other Details:
|
Languages: eng Pagination: 1545-56 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 AACR. |
Affiliation:
|
Fox Chase Cancer Center, Philadelphia, PA 19111, USA. joanne.dorgan@fccc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Bone Density* Breast / anatomy & histology* Breast Neoplasms / prevention & control* Child Cholesterol, LDL / blood Diet Diet, Fat-Restricted* Estradiol / blood Female Follow-Up Studies Gonadal Hormones / blood* Humans Mammography Progesterone / blood Sex Hormone-Binding Globulin / metabolism Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
R01 CA104670-04/CA/NCI NIH HHS; R01CA104670/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cholesterol, LDL; 0/Gonadal Hormones; 0/Sex Hormone-Binding Globulin; 50-28-2/Estradiol; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Urinary biomarkers of oxidative status in a clinical model of oxidative assault.
Next Document: Active and Passive Smoking and the Risk of Pancreatic Cancer in the Netherlands Cohort Study.