Document Detail


Admixture analysis of plasma cholesterol levels in a Jewish population sample in Jerusalem.
MedLine Citation:
PMID:  6745957     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The frequency distribution of total plasma cholesterol levels (TC) in 17-year-old Jerusalem youngsters and their parents (n = 6,170) was examined for evidence of admixture of normal distributions. Probability plots indicated bimodality of age-adjusted TC in both sexes. Using a maximum likelihood procedure, two normal distributions fitted the age- and sex-adjusted data significantly better than 1, with 0.9% males and 1.2% females coming from a lower distribution 2-3 standard deviations below the major mode and 0.2% males and 1.1% females belonging to the higher distribution. These results suggest that single genes may determine high as well as low cholesterol levels, but are open to other interpretations, and thus require confirmation by segregation analysis. Jews originating from Europe showed the highest TC levels followed by those from Israel, Asia, and Africa. Adjustment of TC for ethnicity did not alter the above estimates. Analysis of bimodality within countries of origin showed greater separation of the distributions in Asian and Israeli origin groups than in European and North African groups, in whom there was less evidence for admixture.
Authors:
Y Friedlander; J D Kark; T Cohen; N A Kaufmann; S Eisenberg; Y Stein
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Human heredity     Volume:  34     ISSN:  0001-5652     ISO Abbreviation:  Hum. Hered.     Publication Date:  1984  
Date Detail:
Created Date:  1984-09-17     Completed Date:  1984-09-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0200525     Medline TA:  Hum Hered     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  82-95     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cholesterol / blood*
Female
Humans
Israel
Jews*
Lipoproteins, HDL / blood
Male
Middle Aged
Triglycerides / blood
Grant Support
ID/Acronym/Agency:
N01-HV-5-3015-L/HV/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Lipoproteins, HDL; 0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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