Document Detail

Admission clinical and electrocardiographic characteristics predicting an increased risk for early reinfarction after thrombolytic therapy.
MedLine Citation:
PMID:  9588409     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study assessed the ability of clinical and electrocardiographic variables routinely obtained on admission to identify patients with acute myocardial infarction treated with thrombolytic therapy at risk of early reinfarction. METHODS AND RESULTS: The study included 2602 patients who received thrombolytic therapy for acute myocardial infarction. Baseline demographic variables and admission clinical and electrocardiographic variables were compared between patients with and without reinfarction. Multivariable logistic regression technique was used and included recurrent infarction as the dependent variable, and baseline demographic, clinical, and electrocardiographic variables as independent variables. History of hypertension (odds ratio [OR] 1.52, 95% confidence interval [CI] 1.00 to 2.31) and diabetes mellitus (OR 1.59, 95% CI 1.00 to 2.53) were associated with a higher risk, and current smoking was associated with a lower risk (OR [no versus yes] 1.64, 95% CI 1.05 to 2.58) of early hospital reinfarction. Distortion of the terminal portion of the QRS complex (OR 1.86, 95% CI 1.20 to 2.87) and absence of abnormal Q waves on admission (OR 1.54, 95% CI 0.98 to 2.43) were associated with increased risk of early reinfarction. CONCLUSIONS: A simple electrocardiographic sign is a reliable predictor of early reinfarction among patients who receive thrombolytic therapy for acute myocardial infarction.
Y Birnbaum; I Herz; S Sclarovsky; B Zlotikamien; A Chetrit; L Olmer; G I Barbash
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  135     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-05-19     Completed Date:  1998-05-19     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  805-12     Citation Subset:  AIM; IM    
Beilinson Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Petah-Tiqua, Israel.
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MeSH Terms
Confidence Intervals
Diabetes Complications
Diabetes Mellitus / mortality
Hospital Mortality
Hypertension / complications,  mortality
Middle Aged
Myocardial Infarction / diagnosis,  drug therapy*,  mortality
Patient Admission*
Reproducibility of Results
Risk Factors
Smoking / adverse effects,  epidemiology
Survival Rate
Thrombolytic Therapy*

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