Document Detail

Admission Hyperglycemia Is Associated with Failed Reperfusion Following Fibrinolytic Therapy in Patients with STEMI: Results of a Retrospective Study.
MedLine Citation:
PMID:  25424148     Owner:  NLM     Status:  Publisher    
BACKGROUND: Hyperglycemia on admission is associated with increased mortality rates in patients with ST-elevation myocardial infarction (STEMI) who are treated with either fibrinolytic therapy (FT) or primary percutaneous coronary intervention (PCI). However, data regarding the relationship between hyperglycemia and the success of FT are lacking. The aim of this study was to investigate the value of admission blood glucose for the prediction of failed reperfusion following FT.
METHODS AND RESULTS: This is a retrospective study of 304 STEMI patients who received FT and whose admission glucose levels were recorded. The main outcome measure was ST segment resolution ≥50 %. The median (interquartile range [IQR]) blood glucose level in the entire study group was 112 (95-153). In 92 (30.2 %) patients, FT was unsuccessful and rescue PCI was performed. Admission glucose (126 [99-192] vs. 110 [94-144] mg/dL, p < 0.001), time from symptom onset to FT (180 [120-270] vs. 150 [120-180] min, p = 0.009), and maximum ST elevation amplitude (3 [2-7] vs. 3 [2-6] mm, p = 0.05) were higher in the failed reperfusion group than in the reperfusion group. Admission hyperglycemia was an independent predictive factor for failed reperfusion (hazard ratio 4.79 [1.80-12.76], p = 0.002), along with time from symptom onset to fibrinolysis and anterior wall myocardial infarction.
CONCLUSIONS: In patients with STEMI who undergo FT, admission hyperglycemia is an independent predictor of the failure of fibrinolysis.
Cuneyt Kocas; Okay Abaci; Gulumser Sevgin Halil; Sukru Arslan; Gokhan Cetinkal; Cem Bostan; Ugur Coskun; Ahmet Yildiz; Murat Ersanli
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-26
Journal Detail:
Title:  American journal of cardiovascular drugs : drugs, devices, and other interventions     Volume:  -     ISSN:  1179-187X     ISO Abbreviation:  Am J Cardiovasc Drugs     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-26     Completed Date:  -     Revised Date:  2014-11-27    
Medline Journal Info:
Nlm Unique ID:  100967755     Medline TA:  Am J Cardiovasc Drugs     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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