| Admission ECG predicts long-term outcome in acute coronary syndromes without ST elevation. | |
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MedLine Citation:
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PMID: 16877473 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Acute coronary syndromes (ACS) without ST elevation are a frequent cause of hospital admission, myocardial infarction and death. AIM: To explore the role of the ECG in stratifying ACS patients. DESIGN: Prospective, centrally-coordinated multicentre registry involving 56 centres throughout the UK. METHODS: Consecutive patients admitted with ACS without ST elevation on the presenting ECG (n = 1046) were followed for 6 months. A subgroup (n = 653) were flagged with the UK Office for National Statistics and followed-up for death over 4 years. RESULTS: Mean follow-up for the group as a whole was 2.4 years. In the first 6 months, the death rate was 7.3%. Survival at 1 year was 90.8% (95%CI 88.2%-92.8%); at 45 months it was 77.8% (95%CI 74.1%-81.1%). We compared data in those with ST depression or bundle branch block on the admission ECG (n = 304, 29%) with those with T wave inversion, Q waves and minor ST segment changes (n = 576, 55%) and those with a normal ECG (n = 166, 16%). Their respective incidences of death were 15%, 5% and 2% (p < 0.01) at 6 months, and 38%, 22% and 7% (p < 0.01) at 4 years. DISCUSSION: Rates of adverse events are high in patients admitted to UK hospitals with ACS without ST elevation. The ECG remains a very important and simple discriminator of both short- and long-term risk, enabling more aggressive, proven therapies to be targeted towards those at highest risk. |
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Authors:
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J Collinson; A Bakhai; A Taneja; D Wang; M D Flather |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2006-07-28 |
Journal Detail:
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Title: QJM : monthly journal of the Association of Physicians Volume: 99 ISSN: 1460-2725 ISO Abbreviation: QJM Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-25 Completed Date: 2007-03-19 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 9438285 Medline TA: QJM Country: England |
Other Details:
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Languages: eng Pagination: 601-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Chelsea & Westminster Hospital, 369 Fulham Road, London. julian.collinson@chelwest.nhs.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina, Unstable / mortality* Bundle-Branch Block / epidemiology Electrocardiography* Female Great Britain Humans Male Microvascular Angina / mortality* Middle Aged Myocardial Infarction / mortality* Prognosis Prospective Studies Risk Factors Survival Rate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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