Document Detail

Administration of thiazolidinediones for neuroprotection in ischemic stroke: a pre-clinical systematic review.
MedLine Citation:
PMID:  20964688     Owner:  NLM     Status:  MEDLINE    
Thiazolidinediones (TZDs) may prevent or attenuate CNS injury arising from an ischemic event. We performed meta-analysis of experimental studies in which a TZD (either rosiglitazone or pioglitazone) was administered in a rodent model of focal or global cerebral ischemia. Infarct volume was the primary endpoint for analysis of drug efficacy, and neurological outcome was also assessed. We identified 31 studies through the use of PubMed and Embase, 22 of which met our pre-specified inclusion criteria and were analyzed with the Cochrane Review Manager software. Treatment with TZDs decreased infarct volume and improved neurological outcome regardless of study quality, dose timing, or ischemia model (transient or permanent). Rosiglitazone and pioglitazone were similarly effective in reducing infarct volume and protecting neurologic function. Importantly, the collective data suggest that pre-treatment with a TZD is not required for neuroprotection, although additional studies are clearly needed to define the breadth of the therapeutic window. The data warrant further studies into the potential acute use of TZDs for ischemic stroke therapy in the general population.
Amanda T White; Anne N Murphy
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-10-07
Journal Detail:
Title:  Journal of neurochemistry     Volume:  115     ISSN:  1471-4159     ISO Abbreviation:  J. Neurochem.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-22     Completed Date:  2010-11-23     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  845-53     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Journal of Neurochemistry © 2010 International Society for Neurochemistry.
Department of Pharmacology, University of California San Diego, San Diego, California, USA.
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MeSH Terms
Brain Ischemia / drug therapy*,  prevention & control*
Drug Evaluation, Preclinical / methods
Neuroprotective Agents / administration & dosage*,  therapeutic use
Species Specificity
Stroke / drug therapy*,  prevention & control*
Thiazolidinediones / administration & dosage*,  therapeutic use
Grant Support
Reg. No./Substance:
0/Neuroprotective Agents; 0/Thiazolidinediones

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