Document Detail


Administration of supplemental L-tyrosine with phenelzine: a clinical literature review.
MedLine Citation:
PMID:  25092999     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The subject of this literature review is the alleged relationship between L-tyrosine, phenelzine, and hypertensive crisis. Phenelzine (Nardil(®)) prescribing information notes: "The potentiation of sympathomimetic substances and related compounds by MAO inhibitors may result in hypertensive crises (see WARNINGS). Therefore, patients being treated with NARDIL should not take […] L-tyrosine […]". Interest in the scientific foundation of this claim was generated during routine patient care. A comprehensive literature search of Google Scholar and PubMed revealed no reported cases of hypertensive crisis associated with concomitant administration of L-tyrosine and phenelzine. Review of current US Food and Drug Administration nutritional guidelines relating to ongoing phenelzine studies reveals no mention and requires no consideration of L-tyrosine ingestion in combination with phenelzine. This paper is intended to provide an objective review of the science to then allow the reader to formulate the final opinion.
Authors:
Marty Hinz; Alvin Stein; Ted Cole; Patricia Ryan
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Publication Detail:
Type:  Journal Article; Review     Date:  2014-07-22
Journal Detail:
Title:  Clinical pharmacology : advances and applications     Volume:  6     ISSN:  1179-1438     ISO Abbreviation:  Clin Pharmacol     Publication Date:  2014  
Date Detail:
Created Date:  2014-08-05     Completed Date:  2014-08-05     Revised Date:  2014-08-07    
Medline Journal Info:
Nlm Unique ID:  101564865     Medline TA:  Clin Pharmacol     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  107-10     Citation Subset:  -    
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