Document Detail

Administration of substances to laboratory animals: equipment considerations, vehicle selection, and solute preparation.
MedLine Citation:
PMID:  22330706     Owner:  NLM     Status:  MEDLINE    
Administration of substances to laboratory animals requires careful consideration and planning to optimize delivery of the agent to the animal while minimizing potential adverse experiences from the procedure. The equipment selected to deliver substances to animals depends on the length of the study and the nature of the material being administered. This selection provides a significant opportunity for refining animal treatment. Similarly, when substances are administered as solutions or suspensions, attention should be given to selection of vehicles and methods used for preparing the solutions and suspensions. The research team, veterinarian, technical personnel, and IACUC members should be aware of reasons underlying selection of equipment for substance delivery and should consider carefully how substances will be prepared and stored prior to administration to animals. Failure to consider these factors during experimental planning may result in unintentional adverse effects on experimental animals and confounded results.
Patricia V Turner; Cynthia Pekow; Mary Ann Vasbinder; Thea Brabb
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Association for Laboratory Animal Science : JAALAS     Volume:  50     ISSN:  1559-6109     ISO Abbreviation:  J. Am. Assoc. Lab. Anim. Sci.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2012-02-14     Completed Date:  2012-05-29     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101269489     Medline TA:  J Am Assoc Lab Anim Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  614-27     Citation Subset:  IM    
Department of Pathobiology, University of Guelph, Guelph, Canada.
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MeSH Terms
Animal Care Committees
Animal Welfare*
Animals, Laboratory*
Catheters / standards
Chemistry, Pharmaceutical / methods
Dosage Forms*
Drug Administration Routes*
Drug Implants
Infusion Pumps, Implantable
Laboratory Animal Science / methods*
Syringes / standards
Reg. No./Substance:
0/Dosage Forms; 0/Drug Implants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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