| Administration of steroids after 34 weeks of gestation enhances fetal lung maturity profiles. | |
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MedLine Citation:
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PMID: 20478551 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To estimate the effect of antenatal glucocorticoid administration on fetal lung maturity in pregnancies with known fetal lung immaturity between the 34th and 37th weeks of gestation. STUDY DESIGN: Pregnancies between 34(0/7) and 36(6/7) weeks undergoing amniocentesis to determine fetal lung maturity were targeted. Women with negative results (TDx-FLM-II <45 mg/g) were randomly assigned to intramuscular glucocorticoid injection or no treatment. A repeat TDx-FLM-II test was obtained 1 week after enrollment. RESULTS: Thirty-two women who met inclusion criteria were randomly assigned. Seven women delivered within a week of testing for fetal lung maturity, and were excluded from the analysis. Ten received glucocorticoid and 15 did not. Women assigned to glucocorticoids had a mean increase TDx-FLM-II in 1 week of 28.37 mg/g. Women assigned to no-treatment had an increase of 9.76 mg/g (P < .002). CONCLUSION: A single course of intramuscular glucocorticoids after 34 weeks in pregnancies with documented fetal lung immaturity significantly increases TDx- FLM-II. |
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Authors:
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Anthony Shanks; Gilad Gross; Tammy Shim; Jenifer Allsworth; Yoel Sadovsky; Ibrahim Bildirici |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2010-05-15 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 203 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 47.e1-5 Citation Subset: AIM; IM |
Copyright Information:
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Copyright (c) 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, MO, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Dexamethasone / administration & dosage* Female Fetal Organ Maturity / drug effects* Glucocorticoids / administration & dosage* Humans Infant, Newborn Lung / drug effects*, embryology* Pregnancy Respiratory Distress Syndrome, Newborn / prevention & control |
| Grant Support | |
ID/Acronym/Agency:
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KL2RR024994/RR/NCRR NIH HHS; UL1RR024992/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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