Document Detail


Administration of steroids after 34 weeks of gestation enhances fetal lung maturity profiles.
MedLine Citation:
PMID:  20478551     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To estimate the effect of antenatal glucocorticoid administration on fetal lung maturity in pregnancies with known fetal lung immaturity between the 34th and 37th weeks of gestation.
STUDY DESIGN: Pregnancies between 34(0/7) and 36(6/7) weeks undergoing amniocentesis to determine fetal lung maturity were targeted. Women with negative results (TDx-FLM-II <45 mg/g) were randomly assigned to intramuscular glucocorticoid injection or no treatment. A repeat TDx-FLM-II test was obtained 1 week after enrollment.
RESULTS: Thirty-two women who met inclusion criteria were randomly assigned. Seven women delivered within a week of testing for fetal lung maturity, and were excluded from the analysis. Ten received glucocorticoid and 15 did not. Women assigned to glucocorticoids had a mean increase TDx-FLM-II in 1 week of 28.37 mg/g. Women assigned to no-treatment had an increase of 9.76 mg/g (P < .002).
CONCLUSION: A single course of intramuscular glucocorticoids after 34 weeks in pregnancies with documented fetal lung immaturity significantly increases TDx- FLM-II.
Authors:
Anthony Shanks; Gilad Gross; Tammy Shim; Jenifer Allsworth; Yoel Sadovsky; Ibrahim Bildirici
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2010-05-15
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  203     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-09-03     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47.e1-5     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2010 Mosby, Inc. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, MO, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Dexamethasone / administration & dosage*
Female
Fetal Organ Maturity / drug effects*
Glucocorticoids / administration & dosage*
Humans
Infant, Newborn
Lung / drug effects*,  embryology*
Pregnancy
Respiratory Distress Syndrome, Newborn / prevention & control
Grant Support
ID/Acronym/Agency:
KL2 RR024994/RR/NCRR NIH HHS; KL2RR024994/RR/NCRR NIH HHS; UL1 RR024992/RR/NCRR NIH HHS; UL1RR024992/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Glucocorticoids; 50-02-2/Dexamethasone
Comments/Corrections

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