| Administration of rosmarinic acid reduces cardiopathology and blood pressure through inhibition of p22phox NADPH oxidase in fructose-fed hypertensive rats. | |
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MedLine Citation:
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PMID: 21795992 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Rosmarinic acid (RA), a caffeic acid ester, has insulin-sensitizing and antioxidant effects in high fructose-fed model of insulin resistance (IR). This study investigated whether RA supplementation prevents cardiac abnormalities and hypertension in fructose-fed rats (FFR). Rats fed fructose diet (60g/100g) for 60 days exhibited metabolic abnormalities, rise in plasma and cardiac lipids and whole body IR. The levels of cardiac antioxidants and plasma ferric antioxidant power (FRAP) were significantly reduced in FFR concomitant with increased levels of lipid peroxidation and protein oxidation products. A significant rise in troponin T, creatine kinase-MB, aspartate transaminase and lactate dehydrogenase in plasma FFR was noted. RA supplemention to FFR (10mg/kg from the 16 day) significantly improved insulin sensitivity, reduced lipid levels, oxidative damage and the expression of p22phox subunit of NADPH oxidase and prevented cardiac hypertrophy. Fructose-induced rise in BP was also lowered by RA through decrease in endothelin-1 and angiotensin converting enzyme activity and increase in nitric oxide levels. Histology revealed reduction in myocardial damage in RA-supplemented FFR. These findings suggest that RA acts as a vasoactive substance and a cardioprotector through its antioxidant property. Thus, RA may be useful in reducing the cardiovascular risk associated with IR. |
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Authors:
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Dhanapalan Karthik; Viswanathan Periyasami; Carani Venkatraman Anuradha |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-22 |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: - ISSN: 1533-4023 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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§Department of Biochemistry and Biotechnology; δDepartment of Pathology, Annamalai University, Annamalai Nagar - 608 002, Tamil Nadu, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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