| Administration of recombinant human erythropoietin in patients with gynecological cancer before radical surgery. | |
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MedLine Citation:
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PMID: 16108399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this prospective study was to investigate the efficacy of preoperative administration of recombinant human erythropoietin in patients with gynecological cancer. METHODS: The study included 38 women with gynecological cancer who were divided randomly in two groups. Study group A included 20 women with gynecological cancer who received recombinant human erythropoietin (rHuEPO) plus iron supplementation for ten days before surgery and five days postoperatively. Group B (controls) included 18 patients who received only iron supplementation for the same time period. Blood samples were obtained on days -10, -3, 0, +3, +5, +10. RESULTS: The mean hemoglobin level was significantly higher in group A than in group B on the day of the operation and remained significantly higher postoperatively while an inverse relationship was observed for mean ferritin values in the two groups. CONCLUSION: Preoperative administration of rHuEPO in patients with gynecological cancer seems to be effective in the blood management of these patients. |
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Authors:
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V Dousias; T Stefos; I Navrozoglou; I Staikos; A Ditto; E Paraskevaidis |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Clinical and experimental obstetrics & gynecology Volume: 32 ISSN: 0390-6663 ISO Abbreviation: Clin Exp Obstet Gynecol Publication Date: 2005 |
Date Detail:
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Created Date: 2005-08-19 Completed Date: 2005-11-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802110 Medline TA: Clin Exp Obstet Gynecol Country: Italy |
Other Details:
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Languages: eng Pagination: 129-31 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University Hospital of Ioannina, Ioannina, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Confidence Intervals Dose-Response Relationship, Drug Drug Administration Schedule Erythropoietin, Recombinant / administration & dosage* Female Follow-Up Studies Genital Neoplasms, Female / drug therapy*, mortality, pathology, surgery* Gynecologic Surgical Procedures / methods*, mortality Humans Iron Compounds / administration & dosage* Middle Aged Neoplasm Staging Preoperative Care Probability Prospective Studies Reference Values Risk Assessment Survival Analysis Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Erythropoietin, Recombinant; 0/Iron Compounds |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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