Document Detail

Administration of recombinant human erythropoietin in patients with gynecological cancer before radical surgery.
MedLine Citation:
PMID:  16108399     Owner:  NLM     Status:  MEDLINE    
The purpose of this prospective study was to investigate the efficacy of preoperative administration of recombinant human erythropoietin in patients with gynecological cancer. METHODS: The study included 38 women with gynecological cancer who were divided randomly in two groups. Study group A included 20 women with gynecological cancer who received recombinant human erythropoietin (rHuEPO) plus iron supplementation for ten days before surgery and five days postoperatively. Group B (controls) included 18 patients who received only iron supplementation for the same time period. Blood samples were obtained on days -10, -3, 0, +3, +5, +10. RESULTS: The mean hemoglobin level was significantly higher in group A than in group B on the day of the operation and remained significantly higher postoperatively while an inverse relationship was observed for mean ferritin values in the two groups. CONCLUSION: Preoperative administration of rHuEPO in patients with gynecological cancer seems to be effective in the blood management of these patients.
V Dousias; T Stefos; I Navrozoglou; I Staikos; A Ditto; E Paraskevaidis
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical and experimental obstetrics & gynecology     Volume:  32     ISSN:  0390-6663     ISO Abbreviation:  Clin Exp Obstet Gynecol     Publication Date:  2005  
Date Detail:
Created Date:  2005-08-19     Completed Date:  2005-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802110     Medline TA:  Clin Exp Obstet Gynecol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  129-31     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University Hospital of Ioannina, Ioannina, Greece.
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MeSH Terms
Confidence Intervals
Dose-Response Relationship, Drug
Drug Administration Schedule
Erythropoietin, Recombinant / administration & dosage*
Follow-Up Studies
Genital Neoplasms, Female / drug therapy*,  mortality,  pathology,  surgery*
Gynecologic Surgical Procedures / methods*,  mortality
Iron Compounds / administration & dosage*
Middle Aged
Neoplasm Staging
Preoperative Care
Prospective Studies
Reference Values
Risk Assessment
Survival Analysis
Treatment Outcome
Reg. No./Substance:
0/Erythropoietin, Recombinant; 0/Iron Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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