Document Detail


Administration of raloxifene does not influence 24-hour ambulatory blood pressure of postmenopausal women with osteopenia: a double-blind placebo-controlled study.
MedLine Citation:
PMID:  12748498     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Because estrogens may decrease 24-hour blood pressure of postmenopausal women, we tested the effect of the selective estrogen receptor modulator raloxifene on ambulatory blood pressure. STUDY DESIGN: Postmenopausal women with osteopenia who were otherwise healthy were assigned randomly in a double blind-fashion to receive placebo (n = 16 women) or raloxifene (60 mg/d, n = 16 women). Before and after 4 months, the blood pressure of each woman was monitored every 30 minutes for 41 hours with the use of an ambulatory device. RESULTS: Similar to the placebo outcome, the raloxifene administration did not modify 24-hour daytime (7 AM -11 PM) and nighttime (11 PM -7 AM) blood pressure and heart rate values. Day-night differences and the 24-hour rhythmic variation of mean blood pressure, which was evaluated by cosinor analysis, were also not affected by placebo or by raloxifene. CONCLUSION: Raloxifene does not influence 24-hour blood pressure of postmenopausal women. These data are reassuring for the cardiovascular safety of the long-term raloxifene administration.
Authors:
Angelo Cagnacci; Anna Lisa Zanni; Annibale Volpe
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  188     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-15     Completed Date:  2003-06-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1278-82     Citation Subset:  AIM; IM    
Affiliation:
Institute of Obstetrics and Gynecology, Policlinico di Modena, via del Pozzo 71, 41100 Modena, Italy. cagnacci@unimore.it
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects
Blood Pressure Monitoring, Ambulatory*
Circadian Rhythm
Double-Blind Method
Female
Heart Rate / drug effects
Humans
Middle Aged
Osteoporosis, Postmenopausal / drug therapy,  physiopathology*
Placebos
Raloxifene / administration & dosage*
Selective Estrogen Receptor Modulators / administration & dosage*
Chemical
Reg. No./Substance:
0/Placebos; 0/Selective Estrogen Receptor Modulators; 84449-90-1/Raloxifene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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