| Administration of quinolinic acid in the rat hippocampus induces expression of c-fos and NGFI-A. | |
| | |
MedLine Citation:
|
PMID: 1281256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We have studied the effect of intrahippocampal administration of quinolinic acid (QUIN) on the temporal expression of mRNAs encoding the immediate early genes (IEGs) c-fos and NGFI-A, by in situ hybridization histochemistry. After administration of QUIN to the left hippocampus, expression of mRNA of both IEGs was transiently stimulated. Maximal expression was found between 1 and 3 h. mRNA of both IEGs was simultaneously expressed in the ipsilateral and contralateral sides in the granule cell layer of the dentate gyrus, the pyramidal cell layer of the CA1 and CA3 fields as well as in the cortex. After pretreatment with the non-competitive NMDA antagonist MK-801 (2 mg/kg i.p. -30 min) the increased expression of both IEGs was partially prevented in the hippocampus and completely in the cortex. No inhibition was observed after treatment with the AMPA antagonist NBQX (30 mg/kg i.p. -15, -5 and +10 min). Additional delayed expression of both IEGs was observed in the ipsilateral hippocampus. This expression was related to cell damage. Twelve h after QUIN administration, c-fos and NGFI-A mRNAs were present in the dentate gyrus. After 4 days, only c-fos mRNA was observed in the dentate gyrus and CA1 field while no NGFI-A mRNA was detected. The present results show that the effect of QUIN is mediated by NMDA and not by AMPA receptors. |
| | |
Authors:
|
L Massieu; N Rocamora; J M Palacios; G Mengod; H W Boddeke |
Related Documents
:
|
21280156 - Krüppel-like family of transcription factor 9, a differentiation-associated transcript... 21316706 - Activation of stat3 signal pathway correlates with twist and e-cadherin expression in h... 21177346 - Ripply3, a tbx1 repressor, is required for development of the pharyngeal apparatus and ... 8690026 - Hypertonic stress induces c-fos but not c-jun expression in the human embryonal eue epi... 8275306 - Neuronal beta-amyloid precursor protein gene expression: regulation by aurintricarboxyl... 21784846 - Forced expression of heat shock protein 27 (hsp27) reverses p-glycoprotein (abcb1)-medi... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Brain research. Molecular brain research Volume: 16 ISSN: 0169-328X ISO Abbreviation: Brain Res. Mol. Brain Res. Publication Date: 1992 Nov |
Date Detail:
|
Created Date: 1993-01-11 Completed Date: 1993-01-11 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8908640 Medline TA: Brain Res Mol Brain Res Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 88-96 Citation Subset: IM |
Affiliation:
|
Preclinical Research Sandoz Pharma Ltd., Basle, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Behavior, Animal / drug effects Dizocilpine Maleate / pharmacology* Gene Expression Regulation / drug effects* Genes, fos / genetics* Hippocampus / drug effects* Ibotenic Acid / analogs & derivatives, antagonists & inhibitors In Situ Hybridization Injections, Intraperitoneal Male Oligonucleotide Probes Quinolinic Acid / pharmacology* Quinoxalines / pharmacology* Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid |
| Chemical | |
Reg. No./Substance:
|
0/Oligonucleotide Probes; 0/Quinoxalines; 0/Receptors, N-Methyl-D-Aspartate; 118876-58-7/2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; 2552-55-8/Ibotenic Acid; 77086-22-7/Dizocilpine Maleate; 77521-29-0/alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; 89-00-9/Quinolinic Acid |
| Comments/Corrections | |
Erratum In:
|
Brain Res Mol Brain Res 1993 May;18(3):273 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Molecular and electrophysiological characterization of a allelic variant of the rat alpha 6 GABAA re...
Next Document: Influence of a single injection of cocaine, amphetamine or GBR 12909 on mRNA expression of striatal ...