| Administration of prostacyclin prevents ventricular fibrillation following coronary occlusion in conscious dogs. | |
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MedLine Citation:
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PMID: 6182407 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of prostacyclin (PGI2) on ventricular arrhythmias following 20 min of coronary occlusion and release were studied in 34 conscious dogs. We administered PGI2 at 100 ng/kg/min and did not observe significant changes in heart rate, blood pressure, or systemic vascular resistance. During the control period, heart rate was 97 +/- 30 (mean +/- SEM) vs. 99 +/- 28 in the PGI2-treated group. Mean arterial pressure was 115 +/- 26 mm Hg and 109 +/- 10 mm Hg in the control and PGI2 groups, respectively. Systemic vascular resistance declined minimally from 2,985 +/- 221 dyn . s . cm-5 to 2,484 +/- 135 dyn . s . cm-5 during the PGI2 infusion (p = NS). Following coronary occlusion, the frequency of ventricular fibrillation was reduced from 53% (9/17) in the control group to 6% (1/17) in the PGI2 group (p less than 0.01). Overall 80-min postinfarction survival was 64% in the group receiving PGI2 infusion compared to 24% in the control group (p less than 0.05). The effects of PGI2 in preventing ventricular fibrillation following acute coronary occlusion can be ascribed to a direct action of this prostaglandin on the myocardium, rather than to an indirect effect due to a reduction in systemic vascular resistance. |
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Authors:
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V A Starnes; R K Primm; R L Woosley; J A Oates; J W Hammon |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 4 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1982 Sep-Oct |
Date Detail:
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Created Date: 1982-12-16 Completed Date: 1982-12-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 765-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Cardiac Output / drug effects Coronary Disease / complications*, physiopathology Dogs Dose-Response Relationship, Drug Electrocardiography Epoprostenol / pharmacology* Heart Rate / drug effects Hemodynamics / drug effects Platelet Aggregation / drug effects Prostaglandins / pharmacology* Vascular Resistance / drug effects Ventricular Fibrillation / prevention & control* |
| Grant Support | |
ID/Acronym/Agency:
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GM-15431/GM/NIGMS NIH HHS; RR-05424/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins; 35121-78-9/Epoprostenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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