| Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia. | |
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MedLine Citation:
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PMID: 19892350 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Astaxanthin has been reported to improve dyslipidemia and metabolic syndrome in animals, but such effects in humans are not well known. METHODS: Placebo-controlled astaxanthin administration at doses of 0, 6, 12, 18 mg/day for 12 weeks was randomly allocated to 61 non-obese subjects with fasting serum triglyceride of 120-200mg/dl and without diabetes and hypertension, aged 25-60 years. RESULTS: In before and after tests, body mass index (BMI) and LDL-cholesterol were unaffected at all doses, however, triglyceride decreased, while HDL-cholesterol increased significantly. Multiple comparison tests showed that 12 and 18 mg/day doses significantly reduced triglyceride, and 6 and 12 mg doses significantly increased HDL-cholesterol. Serum adiponectin was increased by astaxanthin (12 and 18 mg/day), and changes of adiponectin correlated positively with HDL-cholesterol changes independent of age and BMI. CONCLUSIONS: This first-ever randomized, placebo-controlled human study suggests that astaxanthin consumption ameliorates triglyceride and HDL-cholesterol in correlation with increased adiponectin in humans. |
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Authors:
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Hiroshi Yoshida; Hidekatsu Yanai; Kumie Ito; Yoshiharu Tomono; Takashi Koikeda; Hiroki Tsukahara; Norio Tada |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-10-14 |
Journal Detail:
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Title: Atherosclerosis Volume: 209 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-26 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 520-3 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Chiba, Japan. hyoshida@jikei.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood* Adult Cholesterol, HDL / blood* Female Humans Hyperlipidemias / blood*, drug therapy Male Middle Aged Triglycerides / blood Xanthophylls / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Cholesterol, HDL; 0/Triglycerides; 0/Xanthophylls; 472-61-7/astaxanthine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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