| Administration of loperamide and addition of wheat bran to the diets of weaner pigs decrease the incidence of diarrhoea and enhance their gut maturation. | |
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MedLine Citation:
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PMID: 19889242 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of fibre inclusion and transit time regulation on the performance, health status, microbial activity and population, physico-chemical characteristics of the hindgut digesta and intestinal morphology in early weaned pigs were examined. For these experiments, wheat bran (WB) was used as fibre source and loperamide as a drug (LOP) to increase the digesta transit time. In Expt 1, a total of 128 early weaned pigs were randomly distributed in a 2 x 2 factorial combination of WB inclusion (0 v. 40 g/kg) and LOP administration (0 v. 0.07 mg/kg body weight) during 13 d. For Expt 2, a total of twenty-four piglets were allotted to three dietary treatments for 15 d with the same basal diet (control diet) as Expt 1; a diet with 80 g/kg of WB and the combination of WB and LOP. In Expt 1, LOP improved the average daily feed intake and average daily gain of the animals (P = 0.001 and 0.007, respectively). The same result was obtained when WB was combined with LOP. The WB-LOP group also showed a higher concentration of SCFA (P = 0.013), acetic acid (P = 0.004) and propionic acid (P = 0.093). On the other hand, WB inclusion reduced the organic matter and crude protein digestibility (P = 0.001) and tended to decrease the enterobacteria population (P = 0.089). In Expt 2, WB increased the butyric acid concentration (P = 0.086). We concluded that the inclusion of WB to modify the intestinal microbiota activity combined with LOP may be beneficial to animal health and performance. |
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Authors:
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Francesc Molist Gasa; Mauro Ywazaki; Arantza G?mez de Segura Ugalde; Rafael Gustavo Hermes; Josep Gasa Gas?; Jos? Francisco P?rez Hern?ndez |
Publication Detail:
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Type: Journal Article Date: 2009-11-05 |
Journal Detail:
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Title: The British journal of nutrition Volume: 103 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-04-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 879-85 Citation Subset: IM |
Affiliation:
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Grup de Nutrici?, Maneig i Benestar Animal, Departament de Ci?ncia Animal i dels Aliments, Universitat Aut?noma de Barcelona, Bellaterra 08193, Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acid
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analysis Animals Antidiarrheals / administration & dosage* Butyric Acid / analysis Diarrhea / prevention & control, veterinary* Diet Dietary Fiber / administration & dosage* Digestion Enterobacteriaceae / growth & development Fatty Acids, Volatile / analysis Feces / chemistry, microbiology Fermentation Gastrointestinal Transit Intestines / chemistry, growth & development*, microbiology Loperamide / administration & dosage* Propionic Acids / analysis Swine Swine Diseases / prevention & control* Weaning Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/Antidiarrheals; 0/Fatty Acids, Volatile; 0/Propionic Acids; 107-92-6/Butyric Acid; 53179-11-6/Loperamide; 64-19-7/Acetic Acid; 79-09-4/propionic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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