Document Detail

Administration of loperamide and addition of wheat bran to the diets of weaner pigs decrease the incidence of diarrhoea and enhance their gut maturation.
MedLine Citation:
PMID:  19889242     Owner:  NLM     Status:  MEDLINE    
The influence of fibre inclusion and transit time regulation on the performance, health status, microbial activity and population, physico-chemical characteristics of the hindgut digesta and intestinal morphology in early weaned pigs were examined. For these experiments, wheat bran (WB) was used as fibre source and loperamide as a drug (LOP) to increase the digesta transit time. In Expt 1, a total of 128 early weaned pigs were randomly distributed in a 2 x 2 factorial combination of WB inclusion (0 v. 40 g/kg) and LOP administration (0 v. 0.07 mg/kg body weight) during 13 d. For Expt 2, a total of twenty-four piglets were allotted to three dietary treatments for 15 d with the same basal diet (control diet) as Expt 1; a diet with 80 g/kg of WB and the combination of WB and LOP. In Expt 1, LOP improved the average daily feed intake and average daily gain of the animals (P = 0.001 and 0.007, respectively). The same result was obtained when WB was combined with LOP. The WB-LOP group also showed a higher concentration of SCFA (P = 0.013), acetic acid (P = 0.004) and propionic acid (P = 0.093). On the other hand, WB inclusion reduced the organic matter and crude protein digestibility (P = 0.001) and tended to decrease the enterobacteria population (P = 0.089). In Expt 2, WB increased the butyric acid concentration (P = 0.086). We concluded that the inclusion of WB to modify the intestinal microbiota activity combined with LOP may be beneficial to animal health and performance.
Francesc Molist Gasa; Mauro Ywazaki; Arantza G?mez de Segura Ugalde; Rafael Gustavo Hermes; Josep Gasa Gas?; Jos? Francisco P?rez Hern?ndez
Publication Detail:
Type:  Journal Article     Date:  2009-11-05
Journal Detail:
Title:  The British journal of nutrition     Volume:  103     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  879-85     Citation Subset:  IM    
Grup de Nutrici?, Maneig i Benestar Animal, Departament de Ci?ncia Animal i dels Aliments, Universitat Aut?noma de Barcelona, Bellaterra 08193, Barcelona, Spain.
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MeSH Terms
Acetic Acid / analysis
Antidiarrheals / administration & dosage*
Butyric Acid / analysis
Diarrhea / prevention & control,  veterinary*
Dietary Fiber / administration & dosage*
Enterobacteriaceae / growth & development
Fatty Acids, Volatile / analysis
Feces / chemistry,  microbiology
Gastrointestinal Transit
Intestines / chemistry,  growth & development*,  microbiology
Loperamide / administration & dosage*
Propionic Acids / analysis
Swine Diseases / prevention & control*
Weight Gain
Reg. No./Substance:
0/Antidiarrheals; 0/Fatty Acids, Volatile; 0/Propionic Acids; 107-92-6/Butyric Acid; 53179-11-6/Loperamide; 64-19-7/Acetic Acid; 79-09-4/propionic acid

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