Document Detail

Administration of glutamate into the spinal cord at extracellular concentrations reached post-injury causes functional impairments.
MedLine Citation:
PMID:  15925447     Owner:  NLM     Status:  MEDLINE    
In vivo experiments addressing the role of released glutamate in damage caused by neurotrauma seldom administer glutamate itself because it usually produces relatively little damage when administered into central nervous system (CNS) tissue in vivo. However, because of recent observations that glutamate administered into the spinal cord at the levels attained following spinal cord injury (SCI) kills neurons and oligodendrocytes, we tested the effects of administering glutamate at those concentrations on locomotor function. The Basso-Beattie-Bresnahan (BBB) test and activity box measures demonstrated that those glutamate concentrations produce lasting functional impairments. Several parameters provided by the activity box provided sensitive measures of the degree of post-SCI impairment, demonstrating their substantial potential for evaluating outcomes of SCI. Results obtained also enhance evidence that glutamate toxicity contributes to secondary damage following SCI and suggest that damage to white matter is an important contributor to such damage.
Guo-Ying Xu; Michael G Hughes; Liping Zhang; Lisa Cain; David J McAdoo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  384     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-06-27     Completed Date:  2005-08-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  271-6     Citation Subset:  IM    
Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1043, USA.
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MeSH Terms
Dose-Response Relationship, Drug
Extracellular Fluid / metabolism
Gait Disorders, Neurologic / chemically induced*,  diagnosis*,  metabolism,  pathology
Glutamic Acid / metabolism,  toxicity*
Neurons / drug effects*,  pathology*
Rats, Sprague-Dawley
Spinal Cord / drug effects*,  pathology
Spinal Cord Injuries / chemically induced*,  diagnosis*,  metabolism,  pathology
Grant Support
Reg. No./Substance:
56-86-0/Glutamic Acid

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