Document Detail

Administration of free radical scavenger edaravone associated with higher frequency of hemorrhagic transformation in patients with cardiogenic embolism.
MedLine Citation:
PMID:  18654047     Owner:  NLM     Status:  MEDLINE    
Free radicals are known to activate coagulation and inhibit fibrinolysis. Edaravone, a free radical scavenger, protects vascular endothelial cells and neurons during acute brain ischemia in in vitro models. Hemorrhagic transformation and treatment outcomes were retrospectively examined in 76 patients with acute cardiogenic embolism treated with edaravone in addition to routine treatment within 24 hours of the onset of symptoms. Hemorrhagic transformation was categorized according to European Cooperative Acute Stroke Study-II. Patient characteristics were also evaluated, including evidence of hypertension, diabetes mellitus, hyperlipidemia, coronary heart disease, history of smoking, National Institutes of Health Stroke Scale on arrival, and modified Rankin scale at 3 months post-onset. Edaravone administration was one of the factors that contributed to increased frequency of hemorrhagic transformation, but had showed no significant relationship with the outcome. The present study showed that edaravone administration increased the frequency of hemorrhagic transformation with heparin in patients with cardiogenic embolism. Free radical scavenging may have promoted the coagulating conditions. Edaravone administration may allow reduction of the dose of heparin and tissue plasminogen activator in patients with acute ischemic stroke.
Masahiro Mishina; Yuichi Komaba; Shiro Kobayashi; Shushi Kominami; Takaharu Fukuchi; Takayuki Mizunari; Akira Teramoto; Yasuo Katayama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurologia medico-chirurgica     Volume:  48     ISSN:  1349-8029     ISO Abbreviation:  Neurol. Med. Chir. (Tokyo)     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-25     Completed Date:  2009-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400775     Medline TA:  Neurol Med Chir (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  292-7     Citation Subset:  IM    
Neurological Institute, Nippon Medical School Chiba-Hokusoh Hospital, Chiba, Japan.
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MeSH Terms
Aged, 80 and over
Antipyrine / administration & dosage,  adverse effects,  analogs & derivatives*
Cerebral Hemorrhage / chemically induced*,  diagnosis
Dose-Response Relationship, Drug
Free Radical Scavengers / administration & dosage,  adverse effects*
Heart Diseases / complications*,  drug therapy
Infusions, Intravenous
Intracranial Embolism / drug therapy*
Middle Aged
Retrospective Studies
Risk Factors
Thrombosis / complications*,  drug therapy
Treatment Outcome
Reg. No./Substance:
0/Free Radical Scavengers; 60-80-0/Antipyrine; 89-25-8/phenylmethylpyrazolone

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