Document Detail

Administration of epinephrine does not increase learning of fear to tone in rats anesthetized with isoflurane or desflurane.
MedLine Citation:
PMID:  15845679     Owner:  NLM     Status:  MEDLINE    
Previous reports suggest that the administration of epinephrine increases learning during deep barbiturate-chloral hydrate anesthesia in rats but not during anesthesia with 0.4% isoflurane in rabbits. We revisited this issue, using fear conditioning to a tone in rats as our experimental model for learning and memory and isoflurane and desflurane as our anesthetics. Expressed as a fraction of the minimum alveolar anesthetic concentration (MAC) preventing movement in 50% of rats, the amnestic 50% effective dose (ED(50)) for fear to tone in control rats inhaling isoflurane and injected with saline intraperitoneally (i.p.) was 0.32 +/- 0.03 MAC (mean +/- se) compared with 0.37 +/- 0.06 MAC in rats injected with 0.01 mg/kg of epinephrine i.p. and 0.38 +/- 0.03 MAC in rats injected with 0.1 mg/kg of epinephrine i.p. For desflurane, the amnestic ED(50) were 0.32 +/- 0.05 MAC in control rats receiving a saline injection i.p. versus 0.36 +/- 0.04 MAC in rats injected with 0.1 mg/kg of epinephrine i.p. We conclude that exogenous epinephrine does not decrease amnesia produced by inhaled isoflurane or desflurane, as assessed by fear conditioning to a tone in rats.
James M Sonner; Yilei Xing; Yi Zhang; Anya Maurer; Michael S Fanselow; Robert C Dutton; Edmond I Eger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  100     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-22     Completed Date:  2005-05-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1333-7, table of contents     Citation Subset:  AIM; IM    
Department of Anesthesia and Perioperative Care S-455, University of California-San Francisco, San Francisco, CA 94143-0464, USA.
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MeSH Terms
Anesthesia, Inhalation
Anesthetics, Inhalation / pharmacology*
Epinephrine / pharmacology*
Isoflurane / analogs & derivatives*,  pharmacokinetics,  pharmacology*
Learning / drug effects*
Rats, Sprague-Dawley
Grant Support
1P01 GM 47818-07/GM/NIGMS NIH HHS
Reg. No./Substance:
0/Anesthetics, Inhalation; 26675-46-7/Isoflurane; 51-43-4/Epinephrine; 57041-67-5/desflurane

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