Document Detail

Administration of a crystalloid fluid preload does not prevent the decrease in arterial blood pressure after induction of anaesthesia with propofol and fentanyl.
MedLine Citation:
PMID:  9771299     Owner:  NLM     Status:  MEDLINE    
Anaesthesia was induced in 58 women (ASA I or II) undergoing elective gynaecological procedures, using propofol 2.5 mg kg-1 and fentanyl 1.5 micrograms kg-1. Patients were allocated to receive 20 ml kg-1 of crystalloid fluid preload over 20 min or to receive no fluids before induction of anaesthesia. A significant decrease in systolic arterial pressure (< 75% of baseline value) occurred in both the fluid-loaded and the control groups, and was similar in both groups. Administration of a fluid preload did not attenuate the decrease in systolic arterial pressure after induction of anaesthesia with propofol and fentanyl.
R J Turner; S P Gatt; P C Kam; I Ramzan; M Daley
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  80     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-10-21     Completed Date:  1998-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  737-41     Citation Subset:  IM    
Prince of Wales Hospital, Randwick, NSW, Australia.
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MeSH Terms
Anesthetics, Intravenous / adverse effects*
Fentanyl / adverse effects
Fluid Therapy
Heart Rate / drug effects
Hypotension / chemically induced,  prevention & control*
Isotonic Solutions
Plasma Substitutes / therapeutic use*
Preoperative Care
Propofol / adverse effects*
Rehydration Solutions / therapeutic use*
Single-Blind Method
Reg. No./Substance:
0/Anesthetics, Intravenous; 0/Isotonic Solutions; 0/Plasma Substitutes; 0/Rehydration Solutions; 0/crystalloid solutions; 2078-54-8/Propofol; 437-38-7/Fentanyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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