Document Detail


Administration of clozapine to a mother rat potentiates pup ultrasonic vocalization in response to separation and re-separation: contrast with haloperidol.
MedLine Citation:
PMID:  21473887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study examined how haloperidol (typical) and clozapine (atypical) treatment to mother rats affected their pups' ultrasonic vocalization (USV) response to maternal separation and re-separation (termed "maternal potentiation"). Clozapine (10 mg/kg, sc) but not haloperidol (0.2 mg/kg, sc) significantly enhanced the maternal potentiation of 40 kHz USVs in pups that were briefly reunited with their dams. This novel paradigm provides an indirect way of assessing the impact of antipsychotic treatment on the quality of maternal care. It may also be useful in examining the impact of antipsychotic treatment on social bonding between infants and mothers.
Authors:
Ming Li; Wei He; Katherine Heupel
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-04-05
Journal Detail:
Title:  Behavioural brain research     Volume:  222     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-05-17     Completed Date:  2011-09-20     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  385-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Clozapine / pharmacology*
Female
Haloperidol / pharmacology*
Male
Maternal Behavior / drug effects
Maternal Deprivation*
Rats
Rats, Sprague-Dawley
Vocalization, Animal / drug effects*
Grant Support
ID/Acronym/Agency:
5R03MH080822-02/MH/NIMH NIH HHS; R03 MH080822/MH/NIMH NIH HHS; R03 MH080822-02/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
J60AR2IKIC/Clozapine; J6292F8L3D/Haloperidol
Comments/Corrections

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