Document Detail

Administration of branched-chain amino acids during sustained exercise--effects on performance and on plasma concentration of some amino acids.
MedLine Citation:
PMID:  1748109     Owner:  NLM     Status:  MEDLINE    
Previous studies have shown that sustained exercise in human subjects causes an increase in the plasma concentration ratio of free tryptophan: other large neutral amino acids [including the branched-chain amino acids (BCAA)]. This should favour the transport of tryptophan into the brain and also the synthesis of 5-hydroxytryptamine, which is thought to contribute to fatigue during prolonged exercise. A mixture of the three BCAA was given to subjects during a 30-km cross-country race or a marathon (42.2 km) and the effects on mental and physical performances were measured. The mental performance, measured as the performance in the Stroop Colour and Word Test (CWT), was improved after, as compared to before the 30-km cross-country race when a BCAA supplement was given during the race, whereas the CWT scores were similar before and after in the placebo group. The running performance in the marathon was improved for the "slower" runners (3.05 h-3.30 h) when BCAA was taken during the race; however, there was no significant effect on the performance in the "faster" runners (less than 3.05 h). The results showed that both mental and physical performance was improved by an intake of BCAA during exercise. In addition, the effects of exercise on the plasma concentration of the aromatic amino acids were altered when a BCAA supplement was given during the marathon.
E Blomstrand; P Hassmén; B Ekblom; E A Newsholme
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  63     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1991  
Date Detail:
Created Date:  1992-01-17     Completed Date:  1992-01-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  83-8     Citation Subset:  IM    
Pripps Bryggerier, Research Laboratories, Bromma, Sweden.
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MeSH Terms
Amino Acids / blood*
Amino Acids, Branched-Chain / pharmacology*
Blood Glucose / metabolism
Exercise / physiology*
Fatty Acids, Nonesterified / blood
Psychomotor Performance / drug effects*
Reg. No./Substance:
0/Amino Acids; 0/Amino Acids, Branched-Chain; 0/Blood Glucose; 0/Fatty Acids, Nonesterified

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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