Document Detail

Administration of atropine in the setting of acute myocardial infarction: potentiation of the ischemic process?
MedLine Citation:
PMID:  11146027     Owner:  NLM     Status:  MEDLINE    
Atropine has also been suggested to potentially worsen the ischemic situation in patients who are in the midst of acute coronary ischemia. We report the case of a female patient with ischemic chest pain and third degree atrioventricular block who developed acute myocardial infarction (AMI) immediately after atropine administration. The use of atropine in this instance remains a reasonable option and should be strongly considered-despite this apparent complication. Undoubtedly in some cases, acute ischemia is intensified by hypoperfusion attributable to vagally mediated bradyarrhythmia; atropine is the antidote for such situations. An awareness of this potential adverse reaction coupled with a prudent selection of candidates for atropine therapy will show the risk/benefit ratio in each individual patient and, therefore, guide the clinician.
W J Brady; A D Perron
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of emergency medicine     Volume:  19     ISSN:  0735-6757     ISO Abbreviation:  Am J Emerg Med     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-24     Completed Date:  2001-03-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8309942     Medline TA:  Am J Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  81-3     Citation Subset:  IM    
Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22906-0114, USA.
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MeSH Terms
Acute Disease
Atropine / adverse effects*
Middle Aged
Myocardial Infarction / chemically induced*
Myocardial Ischemia / complications*,  drug therapy*
Parasympatholytics / adverse effects*
Reg. No./Substance:
0/Parasympatholytics; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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