Document Detail

Administration of antisense DNA for GPR39-1b causes anxiolytic-like responses and appetite loss in rats.
MedLine Citation:
PMID:  22192464     Owner:  NLM     Status:  Publisher    
The G protein-coupled receptor 39-b (GPR39-1b) is a splice variant of GPR39 which is expressed in the central nervous and gastrointestinal systems. Previously, GPR39-1b was proposed to be the receptor for obestatin, but current evidence does not support this hypothesis. The purpose of the present work was to identify the role of GPR39-1b in anxiety and eating behaviors. GPR39-1b antisense oligonucleotides were infused at a constant rate into the cerebral lateral ventricles of rats and their effect on anxiety-like behavior and food intake was monitored. GPR39-1b antisense oligonucleotides produced anxiolytic-like effects in the elevated-plus maze test and in the black and white box test. GPR39-1b antisense oligonucleotides also decreased food intake. These results indicate that inhibition of GPR39-1b induces a decrease in anxiety-related behaviors and disturbs appetite.
Yoshinobu Ishitobi; Jotaro Akiyoshi; Shuhei Honda; Taiga Ninomiya; Masayuki Kanehisa; Yoshihiro Tanaka; Jusen Tsuru; Koichi Isogawa; Hirokazu Kitamura; Yoshihisa Fujikura
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-13
Journal Detail:
Title:  Neuroscience research     Volume:  -     ISSN:  1872-8111     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500749     Medline TA:  Neurosci Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ireland Ltd.
Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Yufu-Shi, Oita 879-5593, Japan.
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