| Administration of antisense DNA for GPR39-1b causes anxiolytic-like responses and appetite loss in rats. | |
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MedLine Citation:
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PMID: 22192464 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The G protein-coupled receptor 39-b (GPR39-1b) is a splice variant of GPR39 which is expressed in the central nervous and gastrointestinal systems. Previously, GPR39-1b was proposed to be the receptor for obestatin, but current evidence does not support this hypothesis. The purpose of the present work was to identify the role of GPR39-1b in anxiety and eating behaviors. GPR39-1b antisense oligonucleotides were infused at a constant rate into the cerebral lateral ventricles of rats and their effect on anxiety-like behavior and food intake was monitored. GPR39-1b antisense oligonucleotides produced anxiolytic-like effects in the elevated-plus maze test and in the black and white box test. GPR39-1b antisense oligonucleotides also decreased food intake. These results indicate that inhibition of GPR39-1b induces a decrease in anxiety-related behaviors and disturbs appetite. |
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Authors:
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Yoshinobu Ishitobi; Jotaro Akiyoshi; Shuhei Honda; Taiga Ninomiya; Masayuki Kanehisa; Yoshihiro Tanaka; Jusen Tsuru; Koichi Isogawa; Hirokazu Kitamura; Yoshihisa Fujikura |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-13 |
Journal Detail:
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Title: Neuroscience research Volume: - ISSN: 1872-8111 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500749 Medline TA: Neurosci Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
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Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Yufu-Shi, Oita 879-5593, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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