Document Detail


Administration of a Peroxynitrite Decomposition Catalyst Into the Bronchial Artery Attenuates Pulmonary Dysfunction After Smoke Inhalation and Burn Injury in Sheep.
MedLine Citation:
PMID:  23042194     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT: Reactive nitrogen species such as peroxynitrite play a significant role in burn and smoke inhalation injury. The bronchial circulation increases more than 10-fold in response to this combination injury. We hypothesized that direct delivery of low dose WW-85, a peroxynitrite decomposition catalyst, into the bronchial artery would attenuate burn and smoke-induced acute lung injury.In adult female sheep (n = 17), the bronchial artery was cannulated in preparation surgery. After a 5-7 day recovery period, sheep were subjected to a burn (40% total body surface area, third degree) and inhalation injury (48 breaths of cotton smoke, <40°C). The animals were divided into three groups following the injury: 1) WW-85 group: 1 h postinjury, WW-85 (0.002 mg/kg/h) was continuously infused into the bronchial artery, n=5; 2) Control group: 1 h post-injury, an equivalent amount of saline was injected into the bronchial artery, n=6; 3) Sham group: no injury, no treatment, same operation and anesthesia, n=6. All animals mechanically ventilated and fluid resuscitated equally.In the control group, the injury induced a severe deterioration of pulmonary oxygenation and shunting and an increase in pulmonary microvascular permeability towards sham. The injury was further associated with an increase in reactive nitrogen species in lung tissues of the control group. All these alterations were significantly attenuated in the WW-85 group.We demonstrated that a low dosage of WW-85 directly administered into the bronchial artery attenuated pulmonary dysfunction to the same extent as higher systemically administered doses in previous experiments. Our data strongly suggest that local airway production of peroxynitrite contributes to pulmonary dysfunction following smoke inhalation and burn injury.
Authors:
Atsumori Hamahata; Perenlei Enkhbaatar; Matthias Lange; Takashi Yamaki; Hiroaki Nakazawa; Motohiro Nozaki; Hiroyuki Sakurai; Lillian D Traber; Daniel L Traber
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-4
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  -     ISSN:  1540-0514     ISO Abbreviation:  Shock     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Tokyo Woman's Medical University, Department of Plastic and Reconstructive Surgery, Tokyo, Japan The University of Texas Medical Branch, Department of Anesthesiology, Galveston, Texas, USA University of Muenster, Department of Anesthesiology and Intensive Care, Muenster, Germany Nihon University School of Medicine, Department of Plastic and Reconstructive Surgery, Tokyo, Japan.
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