| Administration of GM1 ganglioside eliminates neuroleptic-induced sensorimotor deficits in MPTP-treated mice. | |
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MedLine Citation:
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PMID: 2903475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Injection of a low dose of haloperidol, that has no obvious behavioral effects in normal mice, produces akinesia, catalepsy, and sensory neglect in MPTP-treated mice. GM1 ganglioside treatment eliminates all of these behavioral impairments and also partially restores striatal dopamine content. These observations suggest that the MPTP-treated mouse may be a valuable model for studying mechanisms underlying parkinsonism and that administration of GM1 ganglioside may be an effective therapy. |
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Authors:
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F B Weihmuller; M Hadjiconstantinou; J P Bruno; N H Neff |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuroscience letters Volume: 92 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1988 Oct |
Date Detail:
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Created Date: 1988-12-21 Completed Date: 1988-12-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 207-12 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, College of Medicine, Ohio State University, Columbus 43210. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Antipsychotic Agents / pharmacology Behavior, Animal / drug effects Corpus Striatum / drug effects, metabolism*, physiopathology Dopamine / metabolism* G(M1) Ganglioside / therapeutic use* Haloperidol / pharmacology* Male Mice Movement Disorders / chemically induced, drug therapy*, metabolism Pyridines / administration & dosage* |
| Grant Support | |
ID/Acronym/Agency:
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NS23627/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Pyridines; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 37758-47-7/G(M1) Ganglioside; 52-86-8/Haloperidol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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