Document Detail


Administration of GM1 ganglioside eliminates neuroleptic-induced sensorimotor deficits in MPTP-treated mice.
MedLine Citation:
PMID:  2903475     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Injection of a low dose of haloperidol, that has no obvious behavioral effects in normal mice, produces akinesia, catalepsy, and sensory neglect in MPTP-treated mice. GM1 ganglioside treatment eliminates all of these behavioral impairments and also partially restores striatal dopamine content. These observations suggest that the MPTP-treated mouse may be a valuable model for studying mechanisms underlying parkinsonism and that administration of GM1 ganglioside may be an effective therapy.
Authors:
F B Weihmuller; M Hadjiconstantinou; J P Bruno; N H Neff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  92     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-12-21     Completed Date:  1988-12-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  207-12     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, College of Medicine, Ohio State University, Columbus 43210.
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MeSH Terms
Descriptor/Qualifier:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Animals
Antipsychotic Agents / pharmacology
Behavior, Animal / drug effects
Corpus Striatum / drug effects,  metabolism*,  physiopathology
Dopamine / metabolism*
G(M1) Ganglioside / therapeutic use*
Haloperidol / pharmacology*
Male
Mice
Movement Disorders / chemically induced,  drug therapy*,  metabolism
Pyridines / administration & dosage*
Grant Support
ID/Acronym/Agency:
NS23627/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 0/Pyridines; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 37758-47-7/G(M1) Ganglioside; 52-86-8/Haloperidol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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