Document Detail

Administration of a GABAB agonist baclofen before running to exhaustion in the rat: effects on performance and on some indicators of fatigue.
MedLine Citation:
PMID:  9081260     Owner:  NLM     Status:  MEDLINE    
The present study was designed to examine the effects of administration of a GABAergic agonist (Baclofen) on run-time to exhaustion in trained and untrained rats, and on some indicators of fatigue. Run-time to exhaustion on a treadmill set at a speed of 25 m.min-1 was significantly increased in both untrained (p < 0.01) and trained rats (p < 0.005) administered with baclofen one hour before the exercise. The animals who had run the longest time displayed the lowest concentrations of liver and muscle glycogen, and a decrease in plasma glucose concentrations (p < 0.05). The results of this investigation suggest that fatigue during prolonged exercise can be influenced by pharmacological administration of a GABAergic agonist. Indicators of fatigue such as glycemia, liver and muscular glycogen are not the limiting factors of performance and central mechanisms play a key role at exhaustion.
A Abdelmalki; D Merino; D Bonneau; A X Bigard; C Y Guezennec
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of sports medicine     Volume:  18     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-06-03     Completed Date:  1997-06-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  75-8     Citation Subset:  IM; S    
Institut de Médecine Aérospatiale du Service de Santé des Armées, Brétigny sur Orge, France.
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MeSH Terms
Analysis of Variance
Baclofen / pharmacology*
Blood Glucose / analysis
Fatigue / physiopathology*
GABA Agonists / pharmacology*
Glycogen / analysis
Liver / drug effects,  metabolism
Motor Activity / drug effects*
Muscle, Skeletal / drug effects,  metabolism
Physical Conditioning, Animal
Physical Endurance / drug effects*
Rats, Wistar
Running / physiology*
Time Factors
Reg. No./Substance:
0/Blood Glucose; 0/GABA Agonists; 0/Placebos; 1134-47-0/Baclofen; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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