| Administration of D-Alanine-[Ang-(1-7)] (A-779) Prior to Pregnancy in Sprague Dawley Rats Produces Antidiuresis in Late Gestation. | |
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MedLine Citation:
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PMID: 19198668 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We previously demonstrated that angiotensin-(1-7) [Ang-(1-7)], which is increased in the kidney and urine during pregnancy, influences normal fluid expansion of pregnancy. These previous studies were completed by chronic administration of the Ang-(1-7) receptor antagonist D-Alanine-[Ang-(1-7)] (A-779) at a dose of 48 mug/kg/hr after the start of pregnancy (gestational days 11-19). To further explore the role of Ang-(1-7) on kidney function during early, middle, and late pregnancy, Sprague Dawley rats were chronically pretreated 8 days prior to pregnancy and throughout pregnancy (gestational days 0-19) with vehicle or A-779 at a dose of 24 mug/kg/hr. Metabolic studies were completed in virgin animals and throughout pregnancy (gestational days 4-5, 14-15, and 18-19). Chow consumption and water intake increased throughout pregnancy while the difference between intake and output (balance) was increased only at late (day 19) pregnancy with both vehicle and A-779 administration. Urine volume and urinary osmolality were significantly increased and decreased respectively throughout pregnancy in vehicle treated rats only. In late (19 day) pregnancy, A-779 administration significantly decreased chow consumption and water intake. In virgin animals, A-779 administration significantly increased urine volume, while during late pregnancy (19 day), urine volume was significantly decreased with A-779 administration. These studies using pretreatment with a lower dose of A-779 prior to pregnancy confirm results of higher dose A-779 administration after the start of pregnancy. These studies show that Ang-(1-7) produces antidiuresis in virgin rats and diuresis in late gestation. Ang-(1-7) also contributes to the enhanced water intake during pregnancy allowing maintenance of the normal volume expanded state despite diuresis. |
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Authors:
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J Joyner; Laa Neves; Cm Ferrario; Kb Brosnihan |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Journal of the American Society of Hypertension : JASH Volume: 2 ISSN: 1933-1711 ISO Abbreviation: J Am Soc Hypertens Publication Date: 2008 |
Date Detail:
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Created Date: 2009-3-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101312518 Medline TA: J Am Soc Hypertens Country: - |
Other Details:
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Languages: ENG Pagination: 425-430 Citation Subset: - |
Affiliation:
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Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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P01 HL051952-110006//NHLBI NIH HHS; P01 HL051952-119002//NHLBI NIH HHS; P01 HL051952-120006//NHLBI NIH HHS; P01 HL051952-129002//NHLBI NIH HHS; P01 HL051952-130006//NHLBI NIH HHS; P01 HL051952-139002//NHLBI NIH HHS; P01 HL051952-140006//NHLBI NIH HHS; P01 HL051952-149002//NHLBI NIH HHS; P01 HL051952-150006//NHLBI NIH HHS; P01 HL051952-159002//NHLBI NIH HHS; R03 HD042631-01//NICHD NIH HHS; R03 HD042631-02//NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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