Document Detail

Administration of D-Alanine-[Ang-(1-7)] (A-779) Prior to Pregnancy in Sprague Dawley Rats Produces Antidiuresis in Late Gestation.
MedLine Citation:
PMID:  19198668     Owner:  NLM     Status:  Publisher    
We previously demonstrated that angiotensin-(1-7) [Ang-(1-7)], which is increased in the kidney and urine during pregnancy, influences normal fluid expansion of pregnancy. These previous studies were completed by chronic administration of the Ang-(1-7) receptor antagonist D-Alanine-[Ang-(1-7)] (A-779) at a dose of 48 mug/kg/hr after the start of pregnancy (gestational days 11-19). To further explore the role of Ang-(1-7) on kidney function during early, middle, and late pregnancy, Sprague Dawley rats were chronically pretreated 8 days prior to pregnancy and throughout pregnancy (gestational days 0-19) with vehicle or A-779 at a dose of 24 mug/kg/hr. Metabolic studies were completed in virgin animals and throughout pregnancy (gestational days 4-5, 14-15, and 18-19). Chow consumption and water intake increased throughout pregnancy while the difference between intake and output (balance) was increased only at late (day 19) pregnancy with both vehicle and A-779 administration. Urine volume and urinary osmolality were significantly increased and decreased respectively throughout pregnancy in vehicle treated rats only. In late (19 day) pregnancy, A-779 administration significantly decreased chow consumption and water intake. In virgin animals, A-779 administration significantly increased urine volume, while during late pregnancy (19 day), urine volume was significantly decreased with A-779 administration. These studies using pretreatment with a lower dose of A-779 prior to pregnancy confirm results of higher dose A-779 administration after the start of pregnancy. These studies show that Ang-(1-7) produces antidiuresis in virgin rats and diuresis in late gestation. Ang-(1-7) also contributes to the enhanced water intake during pregnancy allowing maintenance of the normal volume expanded state despite diuresis.
J Joyner; Laa Neves; Cm Ferrario; Kb Brosnihan
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Publication Detail:
Journal Detail:
Title:  Journal of the American Society of Hypertension : JASH     Volume:  2     ISSN:  1933-1711     ISO Abbreviation:  J Am Soc Hypertens     Publication Date:  2008  
Date Detail:
Created Date:  2009-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101312518     Medline TA:  J Am Soc Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  425-430     Citation Subset:  -    
Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina USA.
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Grant Support
P01 HL051952-110006//NHLBI NIH HHS; P01 HL051952-119002//NHLBI NIH HHS; P01 HL051952-120006//NHLBI NIH HHS; P01 HL051952-129002//NHLBI NIH HHS; P01 HL051952-130006//NHLBI NIH HHS; P01 HL051952-139002//NHLBI NIH HHS; P01 HL051952-140006//NHLBI NIH HHS; P01 HL051952-149002//NHLBI NIH HHS; P01 HL051952-150006//NHLBI NIH HHS; P01 HL051952-159002//NHLBI NIH HHS; R03 HD042631-01//NICHD NIH HHS; R03 HD042631-02//NICHD NIH HHS

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