Document Detail

Administering labelled water to exclusively breast-fed infants in studies involving stable isotope dilution techniques.
MedLine Citation:
PMID:  21390987     Owner:  NLM     Status:  MEDLINE    
Stable isotope techniques using deuterium or (18)O are reference methods for assessing total body water (TBW) for body composition. In combination, they provide total energy expenditure and human milk intake in exclusively breast-fed (EBF) infants. These techniques require an oral administration of an accurately quantified dose of labelled water to infants, who often have no prior experience of consuming water. In the present study, (18)O labelled water was administered to 47 EBF infants at two time points. Route of administration, duration of dosing and spills were quantified and recorded. Eighty-seven out of 94 (92.6%) dose administrations were successful. In two-thirds of dose administrations, >90% of the prepared dose was consumed. Spills ranged from 0.2% to 57%. Approaches to correct for spills can introduce bias in the calculation of TBW. Minimising and recording all dose spills is an important issue for the accuracy and precision of stable isotope techniques, when applied to EBF infants.
Susan Bjerregaard Nielsen; Jonathan C K Wells; Christine Slater; Mary S Fewtrell; John J Reilly
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Isotopes in environmental and health studies     Volume:  47     ISSN:  1477-2639     ISO Abbreviation:  Isotopes Environ Health Stud     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-10     Completed Date:  2011-06-20     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9602611     Medline TA:  Isotopes Environ Health Stud     Country:  England    
Other Details:
Languages:  eng     Pagination:  18-25     Citation Subset:  IM    
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MeSH Terms
Body Composition
Breast Feeding*
Deuterium / administration & dosage,  diagnostic use*
Isotope Labeling / methods*
Oxygen Isotopes / administration & dosage,  diagnostic use*
Radioisotope Dilution Technique*
Grant Support
CZH/4/413//Chief Scientist Office
Reg. No./Substance:
0/Oxygen Isotopes; 059QF0KO0R/Water; AR09D82C7G/Deuterium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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