| Adjuvant radiotherapy in the treatment of pediatric myxopapillary ependymomas. | |
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MedLine Citation:
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PMID: 20806362 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Assess the role of radiotherapy (RT) in the management of primary and recurrent myxopapillary ependymoma (MPE). MATERIALS AND METHODS: We conducted a retrospective review of patients with MPE treated at the Montreal Children's Hospital/McGill University Health Centre between 1985 and 2008. RESULTS: Seven children under the age of 18 were diagnosed and treated for MPE. All patients were treated with surgery to the primary site. Three patients underwent subtotal resection (STR) and received adjuvant post-operative RT. Only one patient who had spinal drop metastases received post-operative RT to the lumbosacral region following complete resection of the primary tumor. After a median follow up of 78 months (range 24-180 months), all patients were alive with controlled disease. The single patient treated with gross total resection (GTR) and adjuvant local radiation remained recurrence free. One of the three patients treated with STR and adjuvant RT had disease progression that was controlled with re-resection and further RT. Two of the three patients treated with surgery alone developed local and disseminated recurrent spinal disease that was controlled by salvage RT. CONCLUSION: Our data support the evolving literature which suggests that GTR alone provides suboptimal disease control in MPE. In our patients, RT resulted in control of residual, metastatic and/or recurrent disease. Routine adjuvant RT may improve outcomes in pediatric MPE. |
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Authors:
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Hani Al-Halabi; José L Montes; Jeffrey Atkinson; Jean-Pierre Farmer; Carolyn R Freeman |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 55 ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-31 Completed Date: 2010-09-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 639-43 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiation Oncology, McGill University Health Centre/Montreal General Hospital, Montreal, Quebec, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Ependymoma / radiotherapy*, surgery Female Humans Male Radiotherapy, Adjuvant / adverse effects Retrospective Studies Spinal Cord Neoplasms / radiotherapy*, surgery |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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