| Adjuvant neuropeptides can improve neuropathic ligament healing in a rat model. | |
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MedLine Citation:
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PMID: 17290418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diminished healing in neuropathic tissues suggests an important regulatory role for peripheral neurogenic factors in connective tissue healing. Although neurogenic factors, including neuropeptides, can induce cell proliferation and influence inflammatory cell chemotaxis in vitro, there is little appreciation of the potential of neuropeptides to affect connective tissue healing in vivo. We created both efferent and afferent peripheral neuropathies in 55 female Wistar rats. First, we showed that neuropathy led to impaired healing of ruptured ligaments. We then showed that local delivery of specific neuropeptides could reverse the functional deficits of these neuropathic ligaments in only 2 weeks. In substance P and vasoactive intestinal peptide-treated medial collateral ligaments (MCLs), the mechanical properties of these healing neuropathic tissues returned to values at or above normally innervated, intact ligaments. In addition, neuropeptide Y stimulated MCL healing in this model. These findings suggest a new paradigm to improve neuropathic soft connective tissue healing. |
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Authors:
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Kelley W Grorud; Kristina T Jensen; Paolo P Provenzano; Ray Vanderby |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of orthopaedic research : official publication of the Orthopaedic Research Society Volume: 25 ISSN: 0736-0266 ISO Abbreviation: J. Orthop. Res. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-07 Completed Date: 2007-06-27 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8404726 Medline TA: J Orthop Res Country: United States |
Other Details:
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Languages: eng Pagination: 703-12 Citation Subset: IM |
Copyright Information:
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(c) 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. |
Affiliation:
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Orthopedic Research Laboratories, Department of Orthopedics and Rehabilitation, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcitonin Gene-Related Peptide / pharmacology Disease Models, Animal Female Femoral Nerve / physiology Ligaments / drug effects*, innervation, physiology Neuropeptide Y / pharmacology Neuropeptides / pharmacology* Peripheral Nervous System Diseases / drug therapy*, physiopathology Rats Rats, Wistar Rupture Substance P / pharmacology Sympathectomy Vasoactive Intestinal Peptide / pharmacology Wound Healing / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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AR 49266/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y; 0/Neuropeptides; 33507-63-0/Substance P; 37221-79-7/Vasoactive Intestinal Peptide; 83652-28-2/Calcitonin Gene-Related Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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