Document Detail

Adjuvant neuropeptides can improve neuropathic ligament healing in a rat model.
MedLine Citation:
PMID:  17290418     Owner:  NLM     Status:  MEDLINE    
Diminished healing in neuropathic tissues suggests an important regulatory role for peripheral neurogenic factors in connective tissue healing. Although neurogenic factors, including neuropeptides, can induce cell proliferation and influence inflammatory cell chemotaxis in vitro, there is little appreciation of the potential of neuropeptides to affect connective tissue healing in vivo. We created both efferent and afferent peripheral neuropathies in 55 female Wistar rats. First, we showed that neuropathy led to impaired healing of ruptured ligaments. We then showed that local delivery of specific neuropeptides could reverse the functional deficits of these neuropathic ligaments in only 2 weeks. In substance P and vasoactive intestinal peptide-treated medial collateral ligaments (MCLs), the mechanical properties of these healing neuropathic tissues returned to values at or above normally innervated, intact ligaments. In addition, neuropeptide Y stimulated MCL healing in this model. These findings suggest a new paradigm to improve neuropathic soft connective tissue healing.
Kelley W Grorud; Kristina T Jensen; Paolo P Provenzano; Ray Vanderby
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of orthopaedic research : official publication of the Orthopaedic Research Society     Volume:  25     ISSN:  0736-0266     ISO Abbreviation:  J. Orthop. Res.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-07     Completed Date:  2007-06-27     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  8404726     Medline TA:  J Orthop Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  703-12     Citation Subset:  IM    
Copyright Information:
(c) 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
Orthopedic Research Laboratories, Department of Orthopedics and Rehabilitation, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA.
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MeSH Terms
Calcitonin Gene-Related Peptide / pharmacology
Disease Models, Animal
Femoral Nerve / physiology
Ligaments / drug effects*,  innervation,  physiology
Neuropeptide Y / pharmacology
Neuropeptides / pharmacology*
Peripheral Nervous System Diseases / drug therapy*,  physiopathology
Rats, Wistar
Substance P / pharmacology
Vasoactive Intestinal Peptide / pharmacology
Wound Healing / drug effects*
Grant Support
Reg. No./Substance:
0/Neuropeptide Y; 0/Neuropeptides; 33507-63-0/Substance P; 37221-79-7/Vasoactive Intestinal Peptide; 83652-28-2/Calcitonin Gene-Related Peptide

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