Document Detail

Adjuvant methotrexate and leucovorin in head and neck squamous cancer. Two-year follow-up of a pilot project.
MedLine Citation:
PMID:  309326     Owner:  NLM     Status:  MEDLINE    
A series of 17 patients with stage III and IV head and neck cancer received three cycles of methotrexate and leucovorin calcium during an interval of two weeks prior to surgery and/or radiotherapy. The dosage of methotrexate was sequentially escalated to produce mucositis (the usual dose-limiting toxicity). All patients have been followed up for a minimum of two years (range, 24 to 44 months). Two recurrences and two second primary tumors occurred in seven patients with stage III cancer, and one recurrence and one postoperative death (pulmonary embolism) occurred in ten patients with stage IV cancer. Seventy-six percent of patients survived, with 71% disease free. Mucositis occurred in 88% but was transient and prevented oral fluid intake in only one patient. Bone marrow suppression was usually mild and did not delay surgery. Escalation of dosage was thought to be important in achieving these encouraging results. A controlled trial is under way to better define the degree of efficacy of this regimen of adjuvant chemotherapy.
S G Taylor; D E Bytell; W D DeWys; E Applebaum; G A Sisson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of otolaryngology (Chicago, Ill. : 1960)     Volume:  104     ISSN:  0003-9977     ISO Abbreviation:  Arch Otolaryngol     Publication Date:  1978 Nov 
Date Detail:
Created Date:  1978-12-20     Completed Date:  1978-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376526     Medline TA:  Arch Otolaryngol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  647-51     Citation Subset:  AIM; IM    
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MeSH Terms
Carcinoma, Squamous Cell / drug therapy*
Drug Therapy, Combination
Head and Neck Neoplasms / drug therapy*
Leucovorin / administration & dosage*,  adverse effects
Methotrexate / administration & dosage*,  adverse effects
Middle Aged
Neoplasm Metastasis
Neoplasm Recurrence, Local
Reg. No./Substance:
58-05-9/Leucovorin; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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