| Adjuvant effects of Lactobacillus casei added to a renutrition diet in a malnourished mouse model. | |
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MedLine Citation:
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PMID: 12058380 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nutritional deficiencies are associated with impaired immune response, affecting the body's defence mechanisms. It is also known that Lactic Acid Bacteria (LAB) and fermented products such us yogurt have immunopotentiator activity and nutritional properties, and could thus be used as a valuable supplement in a renutrition diet. The aim of this study was to determine, in a non-severe malnutrition model, the effective dose of Lactobacillus casei (L. casei), which when is used as an adjuvant in a renutrition diet, would modulate the mucosal immune system and induce recovery of the integrity of the intestinal barrier. The experiments were performed on groups of malnourished and renourished BALB/c mice. They received after milk renutrition a supplement of different doses and periods of L. casei feeding. We measured body weight; hematologic values and serum proteins. We also characterized small intestine immunoglobulin secreting cells, intraepithelial leukocytes, mastocytes and goblet cells. Structural and ultrastructural studies were performed. Our results suggest that impaired gut barrier and mucosal immune function produced by malnutrition can be reversed by L. casei and that the dose of 10(7) cfu/day/mouse administered during 5 consecutive days was the optimal one for recovery of the gut mucosal immune system. The clinical significance of these findings suggests ways for improving mucosal immunity, and generating protection against enteropathogens in hosts immunosuppressed by malnutrition. |
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Authors:
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Cano Paola Gauffin; Graciela Agüero; Gabriela Perdigon |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biocell : official journal of the Sociedades Latinoamericanas de Microscopía Electronica ... et. al Volume: 26 ISSN: 0327-9545 ISO Abbreviation: Biocell Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-06-12 Completed Date: 2002-07-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9438655 Medline TA: Biocell Country: Argentina |
Other Details:
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Languages: eng Pagination: 35-48 Citation Subset: IM |
Affiliation:
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Centro de Referencias para Lactobacilos (CERELA), Chacabuco 145 (4000), Tucumán, Argentina. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Immunoglobulins / biosynthesis Intestine, Small / immunology, pathology Lactobacillus casei* Mice Mice, Inbred BALB C Nutrition Disorders / diet therapy*, immunology, pathology Probiotics / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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