| Adjuvant CCNU (lomustine) and prednisone chemotherapy for dogs with incompletely excised grade 2 mast cell tumors. | |
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MedLine Citation:
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PMID: 19122059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The use of adjuvant 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; lomustine) to treat incompletely excised canine mast cell tumors (MCTs) has not been evaluated. Medical records of 12 dogs with grade 2 MCT treated with incomplete surgical excision and adjuvant CCNU and prednisone chemotherapy were reviewed. Local recurrence rate, metastasis rate, and survival time were evaluated. None of the dogs developed local recurrence or regional/ distant metastases. Two dogs developed fatal liver failure. The 1- and 2-year progression-free rates of surviving dogs were 100% and 77%, respectively. Postoperative adjuvant CCNU appears to be a useful alternative to radiation therapy for incompletely excised canine cutaneous MCTs. |
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Authors:
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Kenji Hosoya; William C Kisseberth; Francisco J Alvarez; Ana Lara-Garcia; Gillian Beamer; Paul C Stromberg; C Guillermo Couto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Animal Hospital Association Volume: 45 ISSN: 1547-3317 ISO Abbreviation: J Am Anim Hosp Assoc Publication Date: 2009 Jan-Feb |
Date Detail:
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Created Date: 2009-01-05 Completed Date: 2009-03-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0415027 Medline TA: J Am Anim Hosp Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 14-8 Citation Subset: IM |
Affiliation:
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Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon L. Tharp Street, Columbus, Ohio 43210, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents, Alkylating / adverse effects, therapeutic use* Antineoplastic Agents, Hormonal / therapeutic use* Dog Diseases / drug therapy*, surgery Dogs Drug Therapy, Combination Female Liver Failure / etiology, veterinary Lomustine / adverse effects, therapeutic use* Male Mast-Cell Sarcoma / drug therapy, surgery, veterinary* Prednisone / therapeutic use* Retrospective Studies Survival Analysis |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Alkylating; 0/Antineoplastic Agents, Hormonal; 13010-47-4/Lomustine; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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