Document Detail

Adjuncts to mechanical ventilation in ARDS.
MedLine Citation:
PMID:  16766249     Owner:  NLM     Status:  MEDLINE    
Since its first description, acute respiratory distress syndrome has been characterized by abnormal physiologic and gas exchange properties of the lungs. Many adjunctive therapies have been developed to reduce the stresses of mechanical ventilation on already damaged lungs. We examined the mechanism of action and the latest clinical trial information of several adjunctive therapies including prone positioning, nitric oxide, extracorporeal membrane oxygenation, arterial venous carbon dioxide removal, and liquid ventilation. While all of these therapies have demonstrated short-term improvements in arterial blood gases and in the limitation of lung injury, none have shown an evidence-based survival benefit.
James E Lynch; J Mark Cheek; Edward Y Chan; Joseph B Zwischenberger
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in thoracic and cardiovascular surgery     Volume:  18     ISSN:  1043-0679     ISO Abbreviation:  Semin. Thorac. Cardiovasc. Surg.     Publication Date:  2006  
Date Detail:
Created Date:  2006-06-12     Completed Date:  2006-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8917640     Medline TA:  Semin Thorac Cardiovasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20-7     Citation Subset:  IM    
Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555, USA.
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MeSH Terms
Carbon Dioxide / blood
Extracorporeal Circulation / methods
Extracorporeal Membrane Oxygenation
Liquid Ventilation
Nitric Oxide / administration & dosage
Prone Position
Pulmonary Gas Exchange / physiology
Pulmonary Surfactants / therapeutic use
Respiration, Artificial / adverse effects*
Respiratory Distress Syndrome, Adult / physiopathology,  therapy*
Tidal Volume
Reg. No./Substance:
0/Pulmonary Surfactants; 10102-43-9/Nitric Oxide; 124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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