| Adjuncts to physical training of patients with severe COPD: oxygen or noninvasive ventilation? | |
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MedLine Citation:
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PMID: 20587101 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Previous studies have shown positive effects from noninvasive ventilation (NIV) or supplemental oxygen on exercise capacity in patients with COPD. However, the best adjunct for promoting physiologic adaptations to physical training in patients with severe COPD remains to be investigated. METHODS: Twenty-eight patients (mean +/- SD age 68 +/- 7 y) with stable COPD (FEV(1) 34 +/- 9% of predicted) undergoing an exercise training program were randomized to either NIV (n = 14) or supplemental oxygen (n = 14) during group training to maintain peripheral oxygen saturation (S(pO2)) >/= 90%. Physical training consisted of treadmill walking (at 70% of maximal speed) 3 times a week, for 6 weeks. Patients were assessed at baseline and after 6 weeks. Assessments included physiological adaptations during incremental exercise testing (ratio of lactate concentration to walk speed, oxygen uptake [V (O2)], and dyspnea), exercise tolerance during 6-min walk test, leg fatigue, maximum inspiratory pressure, and health-related quality of life. RESULTS: Two patients in each group dropped out due to COPD exacerbations and lack of exercise program adherence, and 24 completed the training program. Both groups improved 6-min walk distance, symptoms, and health-related quality of life. However, there were significant differences between the NIV and supplemental-oxygen groups in lactate/speed ratio (33% vs -4%), maximum inspiratory pressure (80% vs 23%), 6-min walk distance (122 m vs 47 m), and leg fatigue (25% vs 11%). In addition, changes in S(pO2)/speed, V (O2), and dyspnea were greater with NIV than with supplemental-oxygen. CONCLUSIONS: NIV alone is better than supplemental oxygen alone in promoting beneficial physiologic adaptations to physical exercise in patients with severe COPD. |
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Authors:
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Audrey Borghi-Silva; Renata Gonçalves Mendes; Andreza Cristina Toledo; Luciana Maria Malosá Sampaio; Tatiane Patrocínio da Silva; Luciana Noemi Kunikushita; Hugo Celso Dutra de Souza; Tânia F Salvini; Dirceu Costa |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Respiratory care Volume: 55 ISSN: 0020-1324 ISO Abbreviation: Respir Care Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-30 Completed Date: 2010-08-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7510357 Medline TA: Respir Care Country: United States |
Other Details:
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Languages: eng Pagination: 885-94 Citation Subset: IM |
Affiliation:
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Cardiopulmonary Physiotherapy Laboratory, Physiotherapy Department, Federal University of São Carlos, São Carlos, Washington Luis, Km 235 São Carlos, São Paulo 13565-905, Brazil. audrey@ufscar.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Aged Exercise Test Exercise Therapy / methods* Female Humans Male Muscle Strength / physiology Oxygen Inhalation Therapy / methods* Positive-Pressure Respiration / methods* Pulmonary Disease, Chronic Obstructive / physiopathology, therapy* Quality of Life Questionnaires Statistics, Nonparametric Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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