Document Detail


Adjunctive trichloroacetic Acid therapy enhances squaric Acid response to verruca vulgaris.
MedLine Citation:
PMID:  23134989     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Squaric acid dibutyl ester (SADBE) is a commonly used treatment for verruca vulgaris of childhood. Few studies, however, have examined the role of SADBE in combination with other topical therapies for warts. We sought to determine if trichloroacetic acid 50% (TCA) and/or cantharidin 0.7% improve therapeutic response to SADBE. A retrospective chart review of 74 patients who were treated for warts at a pediatric dermatology practice in 2010 was performed. Cox regression analysis was used to identify determinants of 100% response to SADBE and found that number of warts was most important (P=0.002). Trichloroacetic acid + SADBE resulted in 100% clearance of warts in all subjects with the shortest time-to-clearance (hazard ratio [HR]: 2.45, 95% confidence interval [CI]: 1.14-5.25, P=0.02). In contrast, addition of cantharidin did not improve response to SADBE (HR: 1.13, 95% CI: 0.60-2.13, P=0.59) or TCA + SADBE (HR: 1.16, 95% CI: 0.65-2.07, P=0.61). These results suggest that combination treatment with TCA 50% and SADBE significantly improves the consistency and speed of SADBE-induced clearance of warts.
Authors:
Jonathan I Silverberg; Nanette B Silverberg
Related Documents :
23666029 - 2-ketogluconic acid secretion by incorporation of pseudomonas putida kt 2440 gluconate ...
18175899 - Purification, characterization, and cdna cloning of a bowman-birk type trypsin inhibito...
24932669 - Forcefield_ncaa: ab initio charge parameters to aid in the discovery and design of ther...
23077789 - Optimization of media composition for d-amino acid oxidase production by trigonopsis va...
12089209 - Glutamine synthetase expression in liver, muscle, stomach and intestine of bostrichthys...
21187079 - Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol.
7419469 - Deacetylation of ps-5, a new beta-lactam compound. iii. enzymological characterization ...
19079939 - Leptin regulation of lipid homeostasis: dietary and metabolic implications.
18378229 - Comparative efficacy of topical antihistamines in an animal model of early phase allerg...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of drugs in dermatology : JDD     Volume:  11     ISSN:  1545-9616     ISO Abbreviation:  J Drugs Dermatol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101160020     Medline TA:  J Drugs Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1228-30     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Apremilast for discoid lupus erythematosus: results of a phase 2, open-label, single-arm, pilot stud...
Next Document:  Pseudoepitheliomatous hyperplasia and transepidermal elimination in lepromatous leprosy: does T-cell...