Document Detail

Adjunctive pharmacologic therapy in percutaneous coronary intervention: Part I antiplatelet therapy.
MedLine Citation:
PMID:  20926950     Owner:  NLM     Status:  In-Data-Review    
Ischemic heart disease is a major cause of morbidity and mortality throughout the world. Percutaneous coronary intervention (PCI) has rapidly evolved from balloon angioplasty to drug-eluting stents over the past 25 years and has become an important treatment option for coronary heart disease. During PCI, atherosclerotic plaque disruption and the endothelium denudation stimulate both platelet aggregation and the thrombus generation. Therefore, pharmacological adjuvant therapies to protect the procedure-related thrombotic complication during PCI are indispensable. In addition to aspirin, whose benefit has been clearly shown in ischemic heart disease, clopidogrel and prasugrel have shown to dramatically reduce the rate of thrombosis after stent placement. The introduction of glycoprotein IIb/IIIa inhibitors has further improved the results of PCI especially in high-risk patients. In addition, several new drugs with antiplatelet or with antithrombin activities are currently under development.
Soo-Joong Kim; Robert P Giugliano; Ik-Kyung Jang
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  22     ISSN:  1473-5830     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  100-12     Citation Subset:  IM    
aDepartment of Cardiology, College of Medicine, Kyung Hee University, Seoul, Korea bBrigham and Women's Hospital, Harvard Medical School cMassachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
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