| Adjunctive mitomycin C in primary trabeculectomy in young adults: a long-term study of case-matched young patients. | |
| | |
MedLine Citation:
|
PMID: 9782425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The purpose of this study was to determine the efficacy of initial mitomycin C (MMC)-augmented trabeculectomy for uncomplicated glaucoma in young patients. METHODS: A retrospective chart review was performed on all glaucoma patients aged between 15 and 40 years without previous surgery that underwent initial trabeculectomy with MMC between 1988 and 1995 at the University Eye Hospital of Cologne. Success (survival) was defined as an intraocular pressure (IOP) of 21 mmHg or lower, with (qualified success) or without (complete success) glaucoma medications. The results were compared with a case-matched control group that did not receive antiproliferative therapy. RESULTS: Eleven eyes of 11 patients fulfilled the inclusion criteria of initial MMC-augmented trabeculectomy. Using cumulative life-table analysis the success rate was 91% at 1 year and 73% at 5 years for the control group. For the MMC group the success rate was 91% at 1 year and 5 years, respectively. At final visit, mean IOP was significantly (P < 0.001) lower for the MMC group (13.3 +/- 3.9 mmHg) than for controls (18.0 +/- 1.3 mmHg). Significant differences were also found in the complication rate: complications associated with excessive aqueous overfiltration, such as shallow anterior chamber (36%), choroidal detachment (45%) and persistent hypotony (27%), featured particularly in the MMC group. Conversely, scarring of the filtering bleb (18%) and Tenon's cysts (18%) were observed exclusively in control eyes. CONCLUSION: The present results suggest that initial MMC trabeculectomy for uncomplicated glaucoma in young patients significantly reduces IOP and number of adjunctive medications, postoperatively, albeit at the price of a high incidence of hypotony. |
| | |
Authors:
|
P C Jacobi; T S Dietlein; G K Krieglstein |
Related Documents
:
|
18535605 - Bimatoprost/timolol fixed combination vs latanoprost/timolol fixed combination in open-... 23152135 - Decompressive hemicraniectomy reduces mortality in an animal model of intracerebral hem... 20385945 - Incidence and clinical characteristics of childhood glaucoma: a population-based study. 20440215 - Combined intravitreal bevacizumab and trabeculectomy with mitomycin c versus trabeculec... 21619985 - Antegrade cerebral perfusion with mild hypothermia for aortic arch replacement: single-... 19201775 - Adalimumab for the treatment of fistulas in patients with crohn's disease. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Volume: 236 ISSN: 0721-832X ISO Abbreviation: Graefes Arch. Clin. Exp. Ophthalmol. Publication Date: 1998 Sep |
Date Detail:
|
Created Date: 1998-12-02 Completed Date: 1998-12-02 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8205248 Medline TA: Graefes Arch Clin Exp Ophthalmol Country: GERMANY |
Other Details:
|
Languages: eng Pagination: 652-7 Citation Subset: IM |
Affiliation:
|
University Eye Hospital of Cologne, Germany. Philipp.Jacobi@uni-koeln.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Chemotherapy, Adjuvant Female Follow-Up Studies Glaucoma / drug therapy*, surgery* Humans Intraocular Pressure Male Mitomycin / therapeutic use* Postoperative Complications Retrospective Studies Trabeculectomy* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
50-07-7/Mitomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bilateral periocular actinic granuloma in a patient with renal failure: a clinicopathologic study.
Next Document: Ocular symptoms in association with antiphospholipid antibodies.