Document Detail

Adjunctive medroxyprogesterone acetate to radical nephrectomy in category M0 renal cell carcinoma. Preliminary report of a prospective randomized trial.
MedLine Citation:
PMID:  6223819     Owner:  NLM     Status:  MEDLINE    
From July 1979 to December 1981, 83 patients from 6 centers in the Lombardy underwent radical nephrectomy for category M0 renal cell carcinoma. Postoperatively they were randomly allocated to adjunctive medroxyprogesterone acetate (MPA) or to a control group. After the first year of follow-up, the relapse rate was 13% in the controls (5 of 38 evaluable patients) versus 28% in the MPA treatment group (9 of 32). Sex steroid receptors were studied in both the tumor and in the surrounding healthy parenchyma by the dextran-coated charcoal technique in 52 of 70 clinically evaluable patients. There was no significant correlation between receptor studies and the relapse rate. Besides, receptors were more often detected in the healthy than in the neoplastic tissue, and values rarely exceeded 10 fmol/mg protein. Due to the negative trend in the MPA treatment group, the admittance of patients to this study was stopped after 120 patients had been accepted.
G Pizzocaro; G Di Fronzo; L Piva; R Salvioni; E Ronchi; V Cappelletti; A Giongo; E Mastroberardino; C Cozzoli; E Dormia; S Minervini; A Zanollo; U Fontanella; R Giannoni; A Maggioni; E Lasio
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European urology     Volume:  9     ISSN:  0302-2838     ISO Abbreviation:  Eur. Urol.     Publication Date:  1983  
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7512719     Medline TA:  Eur Urol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  202-6     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / drug therapy,  surgery,  therapy*
Clinical Trials as Topic
Kidney Neoplasms / drug therapy,  surgery,  therapy*
Medroxyprogesterone / analogs & derivatives*,  therapeutic use
Medroxyprogesterone Acetate
Middle Aged
Neoplasm Recurrence, Local
Postoperative Period
Prospective Studies
Random Allocation
Receptors, Steroid / analysis
Reg. No./Substance:
0/Receptors, Steroid; 520-85-4/Medroxyprogesterone; 71-58-9/Medroxyprogesterone Acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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